Melania Lidia Anton

No ORCID on file · 2 papers in corpus · active 2025

Study types

  • article 2
article 2025
Stearoyl–coenzyme A desaturase enhances cell survival in human uterine leiomyoma
·doi:10.1016/j.xfss.2025.01.005

OBJECTIVE: Stearoyl-CoA desaturase (SCD1) is an enzyme that catalyzes the conversion of saturated delta-9 fatty acids to monounsaturated fatty acids. SCD1 is highly expressed in various cancers and facilitates cancer cell survival, tumor gr…

article 2025
Therapeutic targeting of the tryptophan-kynurenine-aryl hydrocarbon receptor pathway with apigenin in MED12-mutant leiomyoma cells
·doi:10.1038/s41417-025-00881-0

Approximately 77.4% of uterine leiomyomas carry MED12 gene mutations (mut-MED12), which are specifically associated with strikingly upregulated expression and activity of the tryptophan 2,3-dioxygenase (TDO2) enzyme, leading to increased co…