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Summary Familial Episodic Pain Syndrome (FEPS) is a rare inherited disorder characterized by episodes of severe upper-body pain triggered by different stimuli including cold, stress, or fasting. A gain-of-function point mutation (N855S) in…

Patients with endometriosis report increased levels of perceived stress, which correlates with disease severity and pain intensity, creating feedback loops that perpetuate the cycle of endometriosis inflammation, chronic pain syndrome, and …

Pain is influenced by a complex interplay of biological, psychological, and social factors. Sex has emerged as a key determinant of vulnerability to chronic pain and a major risk factor for poor response to available pharmacological treatme…