V O Speights

No ORCID on file · 7 papers in corpus
lab-animal 2009
Prostaglandin E2 Regulates Survival of Human Endometriotic Epithelial and Stromal Cells by Integrating EGFR, NFkB, and Wnt Signaling Pathways Through EP2 and EP4 Receptors.
·doi:10.1093/biolreprod/81.s1.150

Endometriosis is a debilitating disease affects up to 20% of reproductive age women characterized by the presence of functional endometrial glandular epithelium and stroma outside the uterine cavity that results in chronic pelvic pain and i…

lab-animal 2009
Selective inhibition of prostaglandin E2 receptors EP2 and EP4 induces apoptosis of human endometriotic cells through suppression of ERK1/2, AKT, NFkappaB, and beta-catenin pathways and activation of intrinsic apoptotic mechanisms
Molecular Endocrinology ·doi:10.1210/me.2009-0017

Endometriosis is a benign chronic gynecological disease of reproductive-age women characterized by the presence of functional endometrial tissues outside the uterine cavity. It is an estrogen-dependent disease. Current treatment modalities …

lab-animal 2009
Selective Inhibition of Prostaglandin E2 Receptors EP2 and EP4 Induces Apoptosis of Human Endometriotic Cells through Suppression of ERK1/2, AKT, NFκB and β-CATENIN Pathways and Activation of Intrinsic Apoptotic Mechanisms
·doi:10.1210/jcem.94.7.9993

Endometriosis is a benign chronic gynecological disease of reproductive age women characterized by the presence of functional endometrial tissues outside the uterine cavity. It is an estrogen-dependent disease. Current treatment modalities …

2009
Selective inhibition of prostaglandin E2 signaling inhibits migration and invasion of human endometriotic epithelial and stromal cells through multiple mechanisms
·doi:10.1016/j.fertnstert.2009.07.043
lab-animal 2008
Induction of peritoneal endometriosis in nude mice with use of human immortalized endometriosis epithelial and stromal cells: a potential experimental tool to study molecular pathogenesis of endometriosis in humans
Fertility and sterility ·doi:10.1016/j.fertnstert.2008.06.050

OBJECTIVE: To determine whether a mixed population of immortalized human endometriosis epithelial and stromal cells is able to induce peritoneal endometriosis in nude mice. DESIGN: Prospective experimental study. Human immortalized endomet…

lab-animal 2007
0013-7227/08/$15.00/0 Endocrinology 149(3):1180–1189 Printed in U.S.A. Copyright © 2008 by The Endocrine Society doi: 10.1210/en.2007-1168 Cyclooxygenase-2 Regulates Survival, Migration, and Invasion of Human Endometriotic Cells through Multiple Mechanism

by the presence of functional endometrial glandular epithelium and stroma outside the uterine cavity (1–4). Endometriosis usually develops in the pelvic organs such as the peritoneum, ovaries, fallopian tubes, outside surface of the uterus,…

other 2007
Cyclooxygenase-2 regulates survival, migration, and invasion of human endometriotic cells through multiple mechanisms
Endocrinology ·doi:10.1210/en.2007-1168

Endometriosis is a debilitating disease characterized by the presence of functional endometrial glandular epithelium and stroma outside the uterine cavity that affects up to 20% of women of child-bearing age. Cyclooxygenase-2 (COX-2), a rat…