Ponandai-Srinivasan S

article 2023

Bromocriptine inhibits proliferation in the endometrium from women with adenomyosis

Frontiers in endocrinology ·doi:10.3389/fendo.2023.1026168

OBJECTIVE: Bromocriptine treatment has been shown to reduce menstrual bleeding and pain in women with adenomyosis in a pilot clinical trial. The underlying mechanism contributing to the treatment effect is however unknown. The purpose of th…

2022

Antiprogestins reduce epigenetic field cancerization in breast tissue of young healthy women.

Genome medicine ·doi:10.1186/s13073-022-01063-5

BackgroundBreast cancer is a leading cause of death in premenopausal women. Progesterone drives expansion of luminal progenitor cells, leading to the development of poor-prognostic breast cancers. However, it is not known if antagonising pr…

article 2020

Syndecan-1 modulates the invasive potential of endometrioma via TGF-β signalling in a subgroup of women with endometriosis

Human Reproduction ·doi:10.1093/humrep/deaa164

STUDY QUESTION: What is the physiological role of transforming growth factor-beta (TGF-β1) and syndecans (SDC1, SDC4) in endometriotic cells in women with endometriosis? SUMMARY ANSWER: We observed an abnormal, pro-invasive phenotype in a s…

review 2018

DNA methylation alterations—potential cause of endometriosis pathogenesis or a reflection of tissue heterogeneity?†

Biology of reproduction ·doi:10.1093/biolre/ioy067

Alterations in the DNA methylation pattern of endometriotic lesions and endometrium of endometriosis patients have been proposed as one potential factor accompanying the endometriosis development. Although many differentially methylated gen…