Witkin SS — Endo Lab

2019

Evaluation of lysophosphatidic acid in vaginal fluid as a biomarker for ovarian cancer: A pilot study.

European journal of obstetrics & gynecology and reproductive biology: X ·doi:10.1016/j.eurox.2019.100012

There remains a need to differentiate between women with a benign or a malignant adnexal mass prior to surgery. As part of an ongoing evaluation of vaginal fluid compounds as potential tumor biomarkers we evaluated whether vaginal lysophosp…

2019

Insulin-like growth factor-1 and soluble FMS-like tyrosine kinase-1 prospectively predict cancelled IVF cycles.

Journal of assisted reproduction and genetics ·doi:10.1007/s10815-019-01618-3

PurposeTo identify biomarkers that prospectively predict IVF cycle cancellation.MethodsIn this prospective study, sera were obtained prior to any intervention, from women about to undergo an IVF cycle. The sera were assayed by ELISA for lev…

2008

Hyaluronan in follicular fluid and embryo implantation following in vitro fertilization and embryo transfer.

Journal of assisted reproduction and genetics ·doi:10.1007/s10815-008-9268-4

PurposeTo determine whether the concentration of hyaluronan (HA) in follicular fluid predicts implantation success following embryo transfer.MethodsFollicular fluids from 170 IVF patients were tested by ELISA for HA concentration.ResultsThe…

other 2001

Relationship of abnormal vaginal flora, proinflammatory cytokines and idiopathic infertility in women undergoing IVF

The Journal of reproductive medicine

OBJECTIVE: To investigate the prevalence of bacterial vaginosis (BV) and abnormal bacterial vaginal flora in an infertile population and correlate with cervical cytokine production and in vitro fertilization (IVF) outcome. STUDY DESIGN: In…

1999

Circulating heat shock proteins in women with a history of recurrent vulvovaginitis.

Infectious diseases in obstetrics and gynecology ·doi:10.1002/(sici)1098-0997(1999)7:3<128::aid-idog3>3.0.co;2-i

ObjectivePredisposing factors influencing recurrences of bacterial vaginosis (BV) or vaginitis from Candida remain unidentified for most women. As a component of studies to determine host susceptibility factors to genital tract infections i…

1999

Heat shock proteins and heat shock protein-antibody complexes in placental tissues.

Infectious diseases in obstetrics and gynecology ·doi:10.1002/(sici)1098-0997(1999)7:4<180::aid-idog3>3.0.co;2-7

ObjectiveThe relationship between pregnancy outcome and expression of the heat shock proteins (hsps) or hsp-antibody complexes of 60kD (hsp60), 70kD (hsp70), and 90kD (hsp90) in placental tissue and circulating antibodies to hsps was evalua…

1999

Immunity to heat shock proteins and pregnancy outcome.

Infectious diseases in obstetrics and gynecology ·doi:10.1155/s1064744999000083

Heat shock proteins are among the first proteins produced by the zygote after fertilization. In addition, the maternal decidua also expresses heat shock proteins during the early stages of pregnancy. Autoimmunity to heat shock proteins is n…

other 1998

Cell-mediated immunity to human and Escherichia coli 60-kDa heat shock protein in women: association with a history of spontaneous abortion and endometriosis

American journal of reproductive immunology (New York, N.Y. : 1989) ·doi:10.1111/j.1600-0897.1998.tb00385.x

PROBLEM: Heat shock proteins are expressed during early pregnancy and in peritoneal fluids from women with endometriosis. The relationship between a cell-mediated immune response to human 60-kDa heat shock protein (hsp60), spontaneous abort…

1997

International Group for Research in the Immunopathogenesis of Genital Infections: II. International Symposium on Immunopathogenesis of Pregnancy, December 6-7, 1997.

Infectious diseases in obstetrics and gynecology ·doi:10.1155/s1064744997000136

article 1996

Endometriosis: Expression of the 60 kDa heat shock protein in peritoneal fluids from women with endometriosis: implications for endometriosis-associated infertility

Human Reproduction ·doi:10.1093/oxfordjournals.humrep.a019200

Proinflammatory cytokines and activated macrophages and T lymphocytes have been detected in peritoneal fluids of women with endometriosis and may impair fertility. Expression of the 60 kDa heat shock protein (hsp60) is one mechanism leading…