Stephen Palmer

No ORCID on file · 9 papers in corpus
other 2026
Quantifying inflammatory resolution in human menstruation reveals disease-specific failure modes and enables a non-invasive diagnostic for endometriosis
medRxiv : the preprint server for health sciences ·doi:10.64898/2025.12.30.25343168

Inflammatory resolution is essential for tissue health, yet its dynamics remain difficult to study in humans. Menstruation is a recurrent, non-pathological inflammatory process that provides a natural window into inflammation and repair. We…

article 2015
Bentamapimod (JNK Inhibitor AS602801) Induces Regression of Endometriotic Lesions in Animal Models
Reproductive sciences (Thousand Oaks, Calif.) ·doi:10.1177/1933719115600553

Endometriosis is an estrogen (ER)-dependent gynecological disease caused by the growth of endometrial tissue at extrauterine sites. Current endocrine therapies address the estrogenic aspect of disease and offer some relief from pain but are…

article 2015
c-Jun NH2-terminal kinase inhibitor bentamapimod reduces induced endometriosis in baboons: an assessor-blind placebo-controlled randomized study
Fertility and sterility ·doi:10.1016/j.fertnstert.2015.11.022

ObjectiveTo test the hypothesis that the c-Jun NH2-terminal kinase (JNK) inhibitor (JNKI) bentamapimod (AS602801/PGL5001) can reduce induced endometriosis in baboons.DesignProspective randomized placebo-controlled study.SettingNonhuman prim…

review 2012
Biomarkers in reproductive medicine: the promise, and can it be fulfilled?
Fertility and sterility ·doi:10.1016/j.fertnstert.2012.11.019

A biomarker can be used for early diagnosis of a disease, identification of individuals for disease prevention, as a potential drug target, or as a potential marker for a drug response. A biomarker may also limit the use of drug (and theref…

article 2008
Interruption of Inflammatory Pathways with JNK Inhibitors Induces Regression of Human Endometriotic Lesions and Restores Progesterone Receptor Sensitivity in Endometrium and Lesions.
·doi:10.1093/biolreprod/78.s1.113b

Endometriosis is one of the most common causes of chronic pelvic pain, which affects over 70 million adult and adolescent women worldwide. The pathophysiology of endometriosis involves endocrine, inflammatory and angiogenic components and t…

article 2008
JNK Inhibitor AS-01 Causes Regression of Endometriosis and Suppression of Inflammatory Cytokines and Tissue Remodeling Enzymes.
·doi:10.1093/biolreprod/78.s1.168c

Endometriosis is an estrogen dependent gynecological disease that can result in an array of problems from severe chronic pelvic pain to infertility. It is caused by the ectopic growth of the endometrial tissue at extrauterine sites, predomi…

article 2008
TNF-Binding Protein Complex Inhibits TNF-α-Mediated Effects in Human Endometriotic Cell Line.
·doi:10.1093/biolreprod/78.s1.67b

Endometriosis is characterized by the presence of elevated proinflammatory cytokines like TNFα in the peritoneal cavity. Inhibition of TNFα by TNF binding protein-1 (TBP-1), the soluble form of TNFα receptor-1, was effective in animal model…

other 2006
Molecular properties and preclinical pharmacology of JNJ-1250132, a steroidal progesterone receptor modulator that inhibits binding of the receptor to DNA in vitro
Steroids ·doi:10.1016/j.steroids.2006.02.002

Progesterone receptor modulators have diverse potential therapeutic uses, including the treatment of endometriosis, uterine fibroids and breast cancer. Here we describe the molecular properties and preclinical pharmacology of a new steroida…

other 2003
Identification of genes with differential regulation in primate endometrium during the proliferative and secretory phases of the cycle
Endocrine research ·doi:10.1081/erc-120018676

To study gene expression in the endometrium at different stages of the menstrual cycle, differential mRNA display and reverse Northern analysis were performed on uterine tissues from cynomolgus monkeys. Eutopic endometrial RNA was prepared …