Jenkins J

No ORCID on file · 2 papers in corpus

2026

Identification of the Piperidyl Urea Derivative BAY-439 as a Potent and Selective Inhibitor of Human Phospholipase A2 Group V (hPLA2-G5) for the Treatment of Inflammatory Pain

Journal of medicinal chemistry ·doi:10.1021/acs.jmedchem.6c00488

Human Phospholipase A2 Group V (hPLA2-G5) is elevated in inflammatory conditions and promotes neutrophil and macrophage recruitment. Its enzymatic activity activates lipid receptors and cytosolic phospholipase A2 (cPLA2), leading to arachid…

2023

Myoglobin-derived iron causes wound enlargement and impaired regeneration in pressure injuries of muscle.

eLife ·doi:10.7554/elife.85633

The reasons for poor healing of pressure injuries are poorly understood. Vascular ulcers are worsened by extracellular release of hemoglobin, so we examined the impact of myoglobin (Mb) iron in murine muscle pressure injuries (mPI). Tests u…