Klaus Nickisch

No ORCID on file · 4 papers in corpus · active 2013-2020

Study types

  • other 2
  • article 1
  • review 1

Condition tags

  • endometriosis 4
review 2020
A progestin isn’t a progestin: dienogest for endometriosis as a blueprint for future research – Review as a contribution for discussion -
Hormone molecular biology and clinical investigation ·doi:10.1515/hmbci-2020-0013

The different etiopathogenetic mechanisms and the diversity of clinical features of endometriosis has not yet allowed to identify a causal pharmacological monotherapy satisfying the unresolved medical needs in this important female disease.…

article 2016
An efficient model of human endometriosis by induced unopposed estrogenicity in baboons
Oncotarget ·doi:10.18632/oncotarget.7516

// Hareesh B. Nair 1 , Robert Baker 2 , Michael A. Owston 2 , Renee Escalona 2 , Edward J. Dick 2 , John L. VandeBerg 2 and Klaus J. Nickisch 1 1 Evestra, Inc., San Antonio, TX, USA 2 Southwest National Primate Research Center, Texas Biomed…

other 2013
Synthesis and antiprogestational properties of novel 17-fluorinated steroids
Steroids ·doi:10.1016/j.steroids.2013.04.003

Progesterone receptor (PR) plays a key role in reproductive functions, and compounds that inhibit progesterone action (antiprogestins) have potential use in the treatment of estrogen- and progesterone-dependent diseases, including uterine l…

other 2013
Synthesis and biological evaluation of partially fluorinated antiprogestins and mesoprogestins
Steroids ·doi:10.1016/j.steroids.2012.09.010

A series of antiprogestins have been synthesized by partially fluorinating the steroid molecule in positions relevant for receptor binding. By introducing fluorine at the exo-methylene of the 17 spirofuran ring, we obtained partial agonists…