Philip C N Chiu

No ORCID on file · 4 papers in corpus
lab-animal 2026
Endometrial Assembloid Model Reveals Endometrial Gland Development Regulation by Estradiol-Driven WNT7B Suppression
Advanced science (Weinheim, Baden-Wurttemberg, Germany) ·doi:10.1002/advs.202509664

Adult endometrial glands undergo cyclic regeneration and development during the menstrual cycle. Their secretions are vital for endometrial functions and early pregnancy, yet the mechanisms controlling gland development are not well underst…

lab-animal 2025
Single-cell transcriptomics reveals notch regulation in quiescent LEPR⁺ endometrial mesenchymal stem cells
Stem cell research & therapy ·doi:10.1186/s13287-025-04803-7

BACKGROUND: The human endometrium is a regenerative tissue relying on stem/progenitor cells. Endometrial mesenchymal stem cells (eMSCs) are typically enriched using perivascular markers like CD140b and CD146. However, the identity of more p…

lab-animal 2024
Interleukin 6 at menstruation promotes the proliferation and self-renewal of endometrial mesenchymal stromal/stem cells through the WNT/β-catenin signaling pathway
Frontiers in immunology ·doi:10.3389/fimmu.2024.1378863

BACKGROUND: At menstruation, the functional layer of the human endometrium sheds off due to the trigger of the release of inflammatory factors, including interleukin 6 (IL-6), as a result of a sharp decline in progesterone levels, leading t…

review 2022
Three-dimensional culture models of human endometrium for studying trophoblast-endometrium interaction during implantation
Reproductive biology and endocrinology : RB&E ·doi:10.1186/s12958-022-00973-8

During implantation, a symphony of interaction between the trophoblast originated from the trophectoderm of the implanting blastocyst and the endometrium leads to a successful pregnancy. Defective interaction between the trophoblast and end…