John J. Jeffrey — Endo Lab

article 2002

Serotonin-induced MMP-13 Production Is Mediated via Phospholipase C, Protein Kinase C, and ERK1/2 in Rat Uterine Smooth Muscle Cells

·doi:10.1074/jbc.m205094200

Serotonin (5-hydroxytryptamine; 5-HT), acting via the 5-HT(2A) receptor, up-regulates the transcription and production of interstitial collagenase (matrix metalloproteinase-13; MMP-13), a critical enzyme responsible for maintaining the inte…

article 1994

Regulation of uterine collagenase gene expression: interactions between serotonin and progesterone

·doi:10.1016/0303-7207(94)90220-8

This report seeks to further define the requirements for the previously established induction of collagenase gene expression by serotonin and inhibition by progesterone in primary cultures of rat uterine smooth muscle cells. Detectable incr…

article 1992

Regulation of collagenase gene expression by serotonin and progesterone in rat uterine smooth muscle cells.

·doi:10.1016/s0021-9258(19)36750-x

The regulation of collagenase gene expression by serotonin and progesterone was investigated in primary cultures of rat uterine smooth muscle cells. Northern blot analysis demonstrates that serotonin (5-hydroxytryptamine (5-HT)), when admin…

article 1991

Serotonin: An inducer of collagenase in myometrial smooth muscle cells

·doi:10.1002/jcp.1041460310

Rat myometrial smooth muscle cells in culture actively produce collagenase in medium containing fetal bovine serum, but not in medium containing newborn bovine serum or containing fetal serum adsorbed with dextran-coated charcoal. A dialyza…