KOSKIMIES Pasi
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· 8 papers in corpus
lab-animal
2022
Hydroxysteroid (17beta) dehydrogenase type 1 (HSD17B1) is an enzyme that converts estrone to estradiol, while adenomyosis is an estrogen-dependent disease with poorly understood pathophysiology. In the present study, we show that mice unive…
2006
This invention relates to benzo (4, 5) thieno (2, 3-d) pyrimidin-4-one compounds, their 5,6-dihydro and 5, 6, 7, 8-tetrahydro derivatives and their use for the treatment of a steroid hormone dependent disease or disorder, preferably for a s…
2006
This invention relates to benzo (4, 5) thieno (2, 3-d) pyrimidin-4-one compounds, their 5,6-dihydro and 5, 6, 7, 8-tetrahydro derivatives and their use for the treatment of a steroid hormone dependent disease or disorder, preferably for a s…
2006
The present invention relates to novel 3, 15 substituted estrone derivatives which represent inhibitory compounds of the 17beta- hydroxysteroid dehydrogenase type I (17beta-HSD1), to their salts, to pharmaceutical preparations containing th…
2006
The present invention relates to novel 3, 15 substituted estrone derivatives which represent inhibitory compounds of the 17Ã-hydroxysteroid dehydrogenase type I (17Ã-HSD1), to their salts, to pharmaceutical preparations containing these c…
2005
This invention relates to benzo (4, 5) thieno (2, 3-d) pyrimidin-4-one compounds, their 5,6-dihydro and 5, 6, 7, 8-tetrahydro derivatives and their use for the treatment of a steroid hormone dependent disease or disorder, preferably for a s…
2005
3,15-substituted estrone compounds which act as inhibitors of 17beta-hydroxysteroid dehydrogenase type I (17beta-HSD1), salts thereof, pharmaceutical preparations containing such compounds, processes for preparing such compounds, and therap…
2005
The present invention relates to novel 3, 15 substituted estrone derivatives which represent inhibitory compounds of the 17beta-hydroxysteroid dehydrogenase type I (17beta-HSD1), to their salts, to pharmaceutical preparations containing the…