Barry S. Komm

No ORCID on file · 4 papers in corpus
lab-animal 2025
Metabolic and transcriptional effects of bazedoxifene/conjugated estrogens in a model of obesity-associated breast cancer risk
JCI insight ·doi:10.1172/jci.insight.182694

Many risk-eligible women refuse tamoxifen for primary prevention of breast cancer due to concerns about common side effects such as vasomotor symptoms. Tamoxifen may also induce or worsen insulin resistance and hypertriglyceridemia, especia…

lab-animal 2014
Treatment with bazedoxifene and conjugated estrogens results in regression of endometriosis in a murine model
Biology of reproduction ·doi:10.1095/biolreprod.113.114165

Bazedoxifene (BZA), a selective estrogen receptor modulator (SERM), inhibits the action of estrogens on endometrial proliferation. Here, we evaluate the effect of a tissue-selective estrogen complex (TSEC) containing BZA and conjugated estr…

lab-animal 2011
Treatment with bazedoxifene, a selective estrogen receptor modulator, causes regression of endometriosis in a mouse model
Endocrinology ·doi:10.1210/en.2010-1010

Endometriosis is a common estrogen-dependent disorder. Medical treatments currently consist of progestins or GnRH agonists; however, neither is fully effective and both entail significant side effects. Selective estrogen receptor (ER) modul…

other 2002
Signal transduction pathways involved in macrophage migration induced by peritoneal fluid chemotactic factors in stages I and II endometriosis
Fertility and sterility ·doi:10.1016/s0015-0282(02)03130-8

OBJECTIVE: To explore the role of G-protein coupled signaling pathways in activation of macrophage migration in endometriosis stages I and II. DESIGN: Case controlled study. SETTING: University hospital. PATIENT(S): Fifteen patients unde…