Kupryjanczyk J — Endo Lab

2025

Special Issue "Biomarkers and Early Detection Strategies of Ovarian Tumors".

International journal of molecular sciences ·doi:10.3390/ijms26189071

Although progress has been made in developing new therapies and deepening the biological understanding of ovarian carcinoma (OvCa), it continues to be the most lethal gynecologic cancer in women [...].

2024

Genome-wide DNA methylation in relation to ARID1A deficiency in ovarian clear cell carcinoma.

Journal of translational medicine ·doi:10.1186/s12967-024-05311-7

BackgroundThe poor chemo-response and high DNA methylation of ovarian clear cell carcinoma (OCCC) have attracted extensive attentions. Recently, we revealed the mutational landscape of the human kinome and additional cancer-related genes an…

2024

Integrative multi-omics analyses to identify the genetic and functional mechanisms underlying ovarian cancer risk regions.

American journal of human genetics ·doi:10.1016/j.ajhg.2024.04.011

To identify credible causal risk variants (CCVs) associated with different histotypes of epithelial ovarian cancer (EOC), we performed genome-wide association analysis for 470,825 genotyped and 10,163,797 imputed SNPs in 25,981 EOC cases an…

2022

Copy Number Variants Are Ovarian Cancer Risk Alleles at Known and Novel Risk Loci.

Journal of the National Cancer Institute ·doi:10.1093/jnci/djac160

BackgroundKnown risk alleles for epithelial ovarian cancer (EOC) account for approximately 40% of the heritability for EOC. Copy number variants (CNVs) have not been investigated as EOC risk alleles in a large population cohort.MethodsSingl…

2022

Polygenic risk modeling for prediction of epithelial ovarian cancer risk.

European journal of human genetics : EJHG ·doi:10.1038/s41431-021-00987-7

Polygenic risk scores (PRS) for epithelial ovarian cancer (EOC) have the potential to improve risk stratification. Joint estimation of Single Nucleotide Polymorphism (SNP) effects in models could improve predictive performance over standard…