Bargagna-Mohan P — Endo Lab

2007

The tumor inhibitor and antiangiogenic agent withaferin A targets the intermediate filament protein vimentin.

Chemistry & biology ·doi:10.1016/j.chembiol.2007.04.010

The natural product withaferin A (WFA) exhibits antitumor and antiangiogenesis activity in vivo, which results from this drug's potent growth inhibitory activities. Here, we show that WFA binds to the intermediate filament (IF) protein, vim…

2006

Development of withaferin A analogs as probes of angiogenesis.

Bioorganic & medicinal chemistry letters ·doi:10.1016/j.bmcl.2006.02.039

The natural product withaferin A (WFA) is a potent angiogenesis inhibitor and it targets the ubiquitin-proteasome pathway in vascular endothelial cells. We generated a biotinylated affinity analog WFA-LC(2)B for use as a probe to study angi…

2005

Use of PROTACS as molecular probes of angiogenesis.

Bioorganic & medicinal chemistry letters ·doi:10.1016/j.bmcl.2005.04.008

Small molecules designed to specifically activate or inactivate protein functions have been useful to study biological processes. PROTACS are small molecule chimera which comprise a ligand and a peptide recognition motif for an E3 ligase. T…