Sugiyama R

IntroductionChronic endometritis (CE) is a persistent inflammatory condition of the endometrium characterized by the infiltration of plasma cells in the endometrial stroma. CD138 immunohistochemistry is considered to improve the CE diagnosi…

PURPOSE: To identify the efficacy of endometrial curettage on antibiotic-resistant chronic endometritis (CE) in infertile women. METHODS: Of 1580 women with CE, 87 with antibiotic-resistant CE after two to five cycles of antibiotic treatme…

Methylenetetrahydrofolate reductase (MTHFR) has various polymorphisms, and the effects of periconceptional folic acid supplementation for decreasing neural tube defects (NTDs) risk differ depending on the genotypes. This study analyzed the …

BackgroundThe aim of this study is to evaluate the relationship between chronic endometritis (CE) and a personalized window of implantation (WOI), identified by results of endometrial receptivity analysis (ERA), and pregnancy outcomes follo…

OBJECTIVE: To elucidate the risk factors associated with resignation from work of Japanese women undergoing infertility treatment. METHODS: A total of 1727 female patients who attended a private fertility clinic in Japan participated in th…

STUDY OBJECTIVE: To analyze the clinical outcomes of and predictive factors for the therapeutic effect of combination treatment of preoperative embryo cryopreservation and endoscopic surgery (surgery-assisted reproductive technology [ART] h…

Vitamin D (VD) deficiency is associated with reproductive failure. However, the relationship between VD and maternal immunity remains unclear. We investigated the clinical efficacy of VD in maternal T-helper (Th) cytokines in 276 infertile …

OBJECTIVE: The endometriosis fertility index (EFI) is a novel index for predicting pregnancy after surgery. We investigated the utility of the EFI for predicting the ability to conceive without assisted reproductive technology (ART) treatme…

PURPOSE: To investigate whether clomiphene citrate (CC) affects uterine receptivity or not, we evaluated pregnancy rates (PR) during the hormone replacement cycle (HRC) according to the period between the last day of CC administration and t…

PURPOSE: Follicular fluid (FF) might reflect the environment during follicle and oocyte growth, and an evaluation of oxidative stress in the FF might be useful in predicting oocyte quality. In order to measure the oxidative stress (OS) in t…

AIM: The aim of this study was to observe the insides of the fallopian tubes of patients with unilateral or bilateral endometriomas by using salpingoscopy and evaluate the inner cavity of the fallopian tubes according to our original scorin…

PURPOSE: The purpose of this study was to investigate how many oocytes are needed to achieve an adequate pregnancy rate per 1 oocyte retrieval cycle in mild ovarian stimulation. METHODS: This protocol consisted of clomiphene citrate and re…

PURPOSE: The purpose was to establish a mild ovarian stimulation protocol that would help assisted reproductive technology (ART) units to avoid scheduling on weekends. METHODS: This protocol directed patients to take 50 mg/day of clomiphen…

PURPOSE: To determine whether embryos cultured with a low oxygen level (2%) brought about beneficial effects on the outcome of ART. METHODS: This is a sequential case-control embryo-culture study. Embryos were cultured either with a gas mi…

PURPOSE: We attempted clinical application of a plastic blade, which is a novel cryopreservation device, for vitrification of human embryos and blastocysts. METHODS: Between February 2003 and December 2007, a total of 4,430 Day 3 embryos f…

PURPOSE: To establish an index to predict ART outcomes and to identify infertile patients who need LH supplementation during ovarian stimulation. METHODS: Serum LH concentrations were measured during the mid- and late-follicular phase in 8…