Rubel CA

No ORCID on file · 4 papers in corpus
2016
Cell reports ·doi:10.1016/j.celrep.2016.09.093

Altered progesterone responsiveness leads to female infertility and cancer, but underlying mechanisms remain unclear. Mice with uterine-specific ablation of GATA binding protein 2 (Gata2) are infertile, showing failures in embryo implantati…

2012
FASEB journal : official publication of the Federation of American Societies for Experimental Biology ·doi:10.1096/fj.11-193334

The ovarian steroid progesterone, acting through the progesterone receptor (PR), coordinates endometrial epithelial-stromal cell communication, which is critical for its development and function. PR expression in these cellular compartments…

2010
Biology of reproduction ·doi:10.1095/biolreprod.109.081513

Previous work has identified Indian hedgehog (Ihh) as a major mediator of progesterone signaling during embryo implantation. Ihh acts through its downstream effector smoothened (Smo) to activate the GLI family of transcription factors. In o…

review 2010
Seminars in reproductive medicine ·doi:10.1055/s-0029-1242990

Healthy uterine function depends on the balanced interaction of the ovarian steroids estrogen and progesterone (P4) signaling through their respective receptors. The expression of each receptor is regulated by the other through crucial cros…