Research questionDoes 3-months of gonadotrophin releasing hormone agonist (GnRHa) treatment before IVF improve clinical pregnancy rate in infertile patients with endometriosis?DesignSingle-blind, placebo-controlled clinical trial of 200 inf…
BackgroundDuring cytoplasmic oocyte maturation, Ca(2+) currents are vital for regulating a broad range of physiological processes. Recent studies have demonstrated that DMSO and EG cause large transient increases in intracellular Ca(2+) in …
ObjectiveTo investigate the effect of antiangiogenic treatment on experimental endometriotic lesion nerve fibers.DesignHeterologous mouse model of endometriosis.SettingUniversity Institute IVI, University Hospital La Fe.Animal(s)Ovariectomi…
Previous studies in an experimental mouse model of endometriosis have shown that the dopamine agonist (DA) cabergoline (Cb2) reduces angiogenesis and endometriotic lesions, hypothetically binding to the dopamine receptor type-2 (DRD2). To d…
BACKGROUND: Implantation of a retrogradely-shed endometrium during menstruation requires an adequate blood supply. The endometrium has angiogenic potential, and endometriotic lesions grow in areas with a rich vascularization, suggesting tha…