Mielke MM

Neuroprotective properties of estrogen have poorly translated to reduced neurodegeneration in clinical trials of systemic estrogen replacement therapy. To more directly assess biological processes associated with brain estrogen (estrone, es…

ObjectiveWe examined the long-term effects of premenopausal bilateral oophorectomy (PBO) with or without concurrent or preceding hysterectomy on physical and cognitive function and on odds of chronic conditions.MethodsWe enrolled 274 women …

IMPORTANCE: The association of premenopausal bilateral oophorectomy with parkinsonism and Parkinson disease (PD) remains controversial. OBJECTIVE: To assess whether women who underwent premenopausal bilateral oophorectomy were at increased…

OBJECTIVE: To evaluate trends in the incidence of premenopausal unilateral and bilateral oophorectomy between 1950 and 2018. METHODS: The Rochester Epidemiology Project medical records-linkage system was used to identify all women aged 18-…

ObjectiveTo study the trajectories of metabolic parameters after bilateral oophorectomy.Study designThis population-based cohort study included a random sample of all premenopausal women who underwent bilateral oophorectomy at or before age…

IMPORTANCE: The associations of bilateral oophorectomy among premenopausal women, age at oophorectomy, and use of estrogen therapy after oophorectomy with cognitive performance later in life remain controversial. OBJECTIVE: To investigate …

IMPORTANCE: Restless legs syndrome is a common neurologic disorder that is more prevalent in women than in men, and it has been suggested that female hormones may be involved in the disorder's pathophysiology. OBJECTIVE: To determine wheth…

In this invited review, we discuss some unresolved and controversial issues concerning premature (<40 years) or early (40-45 years) bilateral oophorectomy. First, we clarify the terminology. Second, we summarize the long-term harmful conseq…