Iona McIntyre

No ORCID on file · 4 papers in corpus
lab-animal 2026
Single cell immune landscapes and translational models of endometriosis reveal diagnostic and therapeutic insights
·doi:10.82444/warw.33914980

Endometriosis is a chronic, inflammatory disorder characterised by the presence of extrauterine endometrial-like tissue (endometriotic lesions) within the peritoneal cavity, and is associated with severe symptoms that include chronic pelvic…

lab-animal 2024
Preclinical testing of RRx-001 in mouse models of experimental endometriosis reveals promising therapeutic impacts
·doi:10.1101/2024.08.12.607591

Endometriosis is a chronic inflammatory condition characterised by the presence of ectopic endometrial-like tissue (lesions), reduced fertility and chronic pain. Impacting both the health and psycho-social functioning of millions of women w…

lab-animal 2024
Single-cell analysis identifies distinct macrophage phenotypes associated with pro-disease and pro-resolving functions in the endometriotic niche
·doi:10.1101/2024.03.07.583861

Abstract Endometriosis negatively impacts the health-related quality of life of 190 million women worldwide. Novel advances in non-hormonal treatments for this debilitating condition are desperately needed. Macrophages play a vital role in …

lab-animal 2024
Single-cell analysis identifies distinct macrophage phenotypes associated with prodisease and proresolving functions in the endometriotic niche
Proceedings of the National Academy of Sciences of the United States of America ·doi:10.1073/pnas.2405474121

Endometriosis negatively impacts the health-related quality of life of 190 million women worldwide. Novel advances in nonhormonal treatments for this debilitating condition are desperately needed. Macrophages play a vital role in the pathop…