Antje Elitzsch — Endo Lab

lab-animal 2006

Rapamycin induces regression of endometriotic lesions by inhibiting neovascularization and cell proliferation

British journal of pharmacology ·doi:10.1038/sj.bjp.0706857

BACKGROUND AND PURPOSE: Rapamycin is a widely used drug with antifungal, immunosuppressant and antiangiogenic effects. Herein, we studied whether immunosuppressive doses of rapamycin are capable of influencing endometriotic lesions. EXPERI…

lab-animal 2006

Selective cyclo-oxygenase-2 inhibition induces regression of autologous endometrial grafts by down-regulation of vascular endothelial growth factor-mediated angiogenesis and stimulation of caspase-3-dependent apoptosis

Fertility and sterility ·doi:10.1016/j.fertnstert.2006.05.068

OBJECTIVE: To investigate the effects of selective cyclo-oxygenase-2 (COX-2) inhibition on the angiogenesis and proliferation of endometrial grafts. DESIGN: Intravital fluorescence microscopic study. SETTING: Institute for Clinical and Ex…

lab-animal 2005

Combined inhibition of vascular endothelial growth factor (VEGF), fibroblast growth factor and platelet-derived growth factor, but not inhibition of VEGF alone, effectively suppresses angiogenesis and vessel maturation in endometriotic lesions

Human Reproduction ·doi:10.1093/humrep/dei308

BACKGROUND: Angiogenesis represents the crucial step in the pathogenesis of endometriosis, because endometriotic lesions require neovascularization to establish, proliferate and invade inside the peritoneal cavity. To elucidate the role of …

lab-animal 2005

In vivo analysis of angiogenesis in endometriosis-like lesions by intravital fluorescence microscopy

Fertility and sterility ·doi:10.1016/j.fertnstert.2005.05.010

OBJECTIVE: To establish a novel endometriosis model that allows for repetitive in vivo analyses of angiogenesis in ectopic endometrial tissue. DESIGN: Intravital fluorescence microscopic study. SETTING: Institute for Clinical and Experime…