Renate Louw-du Toit

No ORCID on file · 2 papers in corpus
lab-animal 2023
The transcriptional activity of progestins used in contraception and menopausal hormone therapy via progesterone receptor A is dependent on the density of the receptor
Biochemical and biophysical research communications ·doi:10.1016/j.bbrc.2022.11.077

Studies directly comparing the efficacies and potencies of multiple progestins used in contraception and menopausal hormone therapy (MHT) in parallel via human progesterone receptor isoform A (PR-A) in the same model system are limited, and…

lab-animal 2022
Differential off-target glucocorticoid activity of progestins used in endocrine therapy
Steroids ·doi:10.1016/j.steroids.2022.108998

The glucocorticoid receptor (GR) regulates transcription of genes involved in multiple processes. Medroxyprogesterone acetate (MPA), widely used in the injectable contraceptive Depo-MPA (DMPA), has off-target effects via the GR, which may r…