Shang M

Dichloroacetate (DCA), as a pan-inhibitor of pyruvate dehydrogenase kinase, plays a crucial role in energy metabolism and mitochondrial function. DCA decreases lactic acid synthesis, enhances mitochondrial oxidative phosphorylation, and reg…

OBJECTIVE: To identity whether there is muscle atrophy phenomenon in end-stage kidney disease patients and to detect the level of transcription factor Foxo1 and the activity of ubiquitin-proteasome system. METHODS: Twenty-two patients in c…