Galigniana MD

ORCID: 0000-0002-9130-8574 · 2 papers in corpus · active 2011
2011
FKBP51 and FKBP52 in signaling and disease.
Trends in endocrinology and metabolism: TEM ·doi:10.1016/j.tem.2011.08.001

FKBP51 and FKBP52 are diverse regulators of steroid hormone receptor signaling, including receptor maturation, hormone binding and nuclear translocation. Although structurally similar, they are functionally divergent, which is largely attri…

2011
Regulation of steroid hormone receptor function by the 52-kDa FK506-binding protein (FKBP52).
Current opinion in pharmacology ·doi:10.1016/j.coph.2011.03.010

The large FK506-binding protein FKBP52 has been characterized as an important positive regulator of androgen, glucocorticoid and progesterone receptor signaling pathways. FKBP52 associates with receptor-Hsp90 complexes and is proposed to ha…