BackgroundPeriodontitis has increasingly been recognized for its impact on systemic health. Mendelian Randomization (MR), an emerging causal inference method, effectively overcomes confounding biases in observational studies. To systematica…
BackgroundDysmenorrhea is a cramping pain during menstrual period and the leading cause for recurrent short-term school absenteeism among adolescent girls. However, evidence on the factors associated with the occurrence of dysmenorrhea, sch…
BACKGROUND: Endometriosis is an estrogen-dependent gynecological endocrine condition and a systemic inflammatory disease associated to improper lipid metabolism and increased cardiovascular risk. The Cardiometabolic Index (CMI) is a novel i…
BackgroundColorectal cancer (CRC) is one of the leading causes of cancer-related death worldwide. P21 activated kinase 4 (PAK4) and Breast cancer anti-estrogen resistance 3 (BCAR3) have been reported to be involved in numerous aspects in tu…
BackgroundUndifferentiated pleomorphic sarcoma (UPS) is a malignant tumor that originates in the mesenchymal tissue and is common in the extremities and retroperitoneum. Primary UPS of the duodenal papilla is rare and a distinct clinical en…
BackgroundThis study aimed to investigate the clinical and pathological characteristics, and the recurrence and prognostic factors of borderline ovarian tumors (BOTs).MethodsThe data of 286 patients admitted to hospital and followed up for …
Signal transducer and activator of transcription 4 (STAT4) is a member of the STAT family and localizes to the cytoplasm. STAT4 is phosphorylated after a variety of cytokines bind to the membrane, and then dimerized STAT4 translocates to th…
p53 is a tumor suppressor gene and plays important roles in the etiology of breast cancer. Studies have produced conflicting results concerning the role of p53 codon 72 polymorphism (G>C) on the risk of breast cancer; therefore, a meta-anal…