Ramesh C. Garg — Endo Lab

review 2006

Role of nonhuman primate models in the discovery and clinical development of selective progesterone receptor modulators (SPRMs)

Reproductive biology and endocrinology : RB&E ·doi:10.1186/1477-7827-4-s1-s8

Selective progesterone receptor modulators (SPRMs) represent a new class of progesterone receptor ligands that exert clinically relevant tissue-selective progesterone agonist, antagonist, partial, or mixed agonist/antagonist effects on vari…

review 2003

Asoprisnil (J867): a selective progesterone receptor modulator for gynecological therapy

Steroids ·doi:10.1016/j.steroids.2003.09.008

Asoprisnil is a novel selective steroid receptor modulator that shows unique pharmacodynamic effects in animal models and humans. Asoprisnil, its major metabolite J912, and structurally related compounds represent a new class of progesteron…

review 2002

Selective Progesterone Receptor Modulators (SPRMs)

Annals of the New York Academy of Sciences ·doi:10.1111/j.1749-6632.2002.tb02798.x

Endometriosis, the presence of endometrial tissue outside the uterus, is a progressive, estrogen-dependent disease and occurs nearly exclusively in menstruating women of reproductive age. Pain syndrome, however, represents the major clinica…