Jean F. Cuiné

No ORCID on file · 2 papers in corpus

lab-animal 2007

Evaluation of the impact of surfactant digestion on the bioavailability of danazol after oral administration of lipidic self-emulsifying formulations to dogs

Journal of pharmaceutical sciences ·doi:10.1002/jps.21246

Lipid-based formulations of danazol with varying quantities of included surfactant have been examined in vitro and in vivo. Formulations comprising fatty acid ester surfactants were readily hydrolysed during in vitro digestion, although Cre…

lab-animal 2007

Increasing the proportional content of surfactant (Cremophor EL) relative to lipid in self-emulsifying lipid-based formulations of danazol reduces oral bioavailability in beagle dogs

Pharmaceutical research ·doi:10.1007/s11095-006-9194-z

PURPOSE: To investigate the impact of a change in the proportions of lipid, surfactant and co-solvent on the solubilisation capacity of self-emulsifying formulations of danazol during in vitro dispersion and digestion studies and correlatio…