Brian E. Henderson

OBJECTIVE: Clinical genetic testing is commercially available for rs61764370, an inherited variant residing in a KRAS 3' UTR microRNA binding site, based on suggested associations with increased ovarian and breast cancer risk as well as wit…

A sizable fraction of colorectal cancer (CRC) is expected to be explained by heritable factors, with heritability estimates ranging from 12 to 35% twin and family studies. Genome-wide association studies (GWAS) have successfully identified …

BACKGROUND: Chronic inflammation may play an etiologic role in ovarian and endometrial cancer, and it is hypothesized that nonsteroidal anti-inflammatory drugs (NSAID) decrease the risk of developing these malignancies. No prospective study…

OBJECTIVE: The main objective was to examine the association between simple hysterectomy (without bilateral oophorectomy) and breast cancer risk. Because hysterectomy prevalence varies by ethnicity, the secondary objective was to examine wh…

Abstract There is substantial evidence that smoking produces an ‘anti-oestrogen’ effect (Baron 1984). This important consequence of smoking appears to be the end result of a number of metabolic pathways: altered hepatic metabolism of endoge…

HENDERSON, BRIAN E.; BENTON, BARBARA; COSGROVE, MALCOLM; BAPTISTA, JOYCE; ALDRICH, JAMES; TOWNSEND, DUANE; HART, WILLIAM; MACK, THOMAS M. Author Information