Inevy Seguinot

Endometriosis is an inflammatory, painful gynecologic disease with no cure and limited treatment options. Epigenetics, including histone modifications, play a key role in the etiology of endometriosis, therefore it has been hypothesized tha…

PurposePain in patients with endometriosis is considered a significant source of stress but does not always correlate with severity of the condition. We have demonstrated that stress can worsen endometriosis in an animal model. Here, we tes…

Although the role of vitamin D in endometriosis is still unclear, vitamin D signaling through the vitamin D receptor (VDR) is associated with anti‐proliferative and anti‐inflammatory effects. We previously reported differential VDR expressi…

Prior studies from our laboratory have shown that stress can exacerbate the severity of endometriosis, a chronic gynecological disorder. The vitamin D receptor (VDR), expressed in cycling endometrium, is associated with anti-proliferative a…

Endometriosis is characterized by peritoneal inflammation, infertility and chronic pelvic pain that substantially affect quality of life. Since stress can affect the immune system and recruitment of inflammatory cells it may contribute to t…