Ramzan K

No ORCID on file · 1 paper in corpus

case-report 2026

Pathogenic homozygous PLCZ1 mutation reduces sperm protein levels with a simulated reduction of PIP2 binding: a case report

Reproduction & fertility ·doi:10.1530/raf-25-0085

ABSTRACT: Mammalian oocyte activation is driven by intracellular calcium (Ca2+) oscillations induced by sperm-specific phospholipase C zeta (PLCζ). Sperm PLCζ deficiency is linked to male infertility caused by oocyte activation deficiency. …