Rakesh Chettier

No ORCID on file · 23 papers in corpus
article 2020
Synthetic-lethal interactions between ATR inhibition and functional genetic and proteomic biomarkers to predict responses in endometriosis-associated cancers.
·doi:10.1200/jco.2020.38.15_suppl.e18000

e18000 Background: Endometriosis is a common gynecologic disorder proven to be a precursor to several cancer types. We developed a potent and selective inhibitor (ATRN-119) of a critical DNA damage response (DDR) protein kinase: the ataxia …

article 2019
Cytoskeletal and extra cellular matrix genes are key contributors in the pathogenesis of endometriosis
·doi:10.1016/j.fertnstert.2019.07.329
article 2019
Endometriosis risk allele in Wnt4 may interact with rare mutations in HDAC2 gene
·doi:10.1016/j.fertnstert.2019.07.952
article 2019
Somatic cancer driver mutations in endometriosis lesions contribute to secondary cancer risk
·doi:10.1016/j.fertnstert.2019.07.328
article 2019
Whole exome sequencing identifies hemizygous deletions in the UGT2B28 and USP17L2 genes in a three‑generation family with endometriosis
Molecular medicine reports ·doi:10.3892/mmr.2019.9818

Endometriosis is an enigmatic condition with an unknown etiology and a poorly understood pathogenesis. It is considered to appear from the interplay of many genetic and environmental factors, affecting up to 10% of women and represents a ma…

article 2018
Can genetic markers of endometriosis predict a patient’s responsiveness to leuprolide acetate?
·doi:10.1016/j.fertnstert.2018.07.057
article 2018
Co-existence of endometriosis with 13 non-gynecological co-morbidities: Mutation analysis by whole exome sequencing
Molecular medicine reports ·doi:10.3892/mmr.2018.9521

Endometriosis is an enigmatic condition with an unknown etiology and poorly understood pathogenesis and women with endometriosis represent a high-risk population group for a large category of chronic conditions. The study focused on a 67-ye…

article 2018
Whole exome sequencing identify hemizygous deletions in ugt2b28 and usp17l2 in a three-generation family with endometriosis
·doi:10.1016/j.fertnstert.2018.07.1085
article 2018
Whole exome sequencing of 137 endometriosis patients with a common ancestor in shakespeare’s england
·doi:10.1016/j.fertnstert.2018.07.1103
article 2017
DNA Testing to Predict Endometriosis: Implications for Referral for Minimally Invasive Surgery
·doi:10.1016/j.jmig.2017.08.075
article 2015
Exome sequencing of women with surgically confirmed endometriosis identifies new candidate genes
·doi:10.1016/j.fertnstert.2015.07.208
other 2014
Endometriosis is associated with rare copy number variants
PloS one ·doi:10.1371/journal.pone.0103968

Endometriosis is a complex gynecological condition that affects 6-10% of women in their reproductive years and is defined by the presence of endometrial glands and stroma outside the uterus. Twin, family, and genome-wide association (GWA) s…

article 2014
Evolutionarily recent, exonic mutations are strong genetic risk factors for endometrosis
·doi:10.1016/j.fertnstert.2014.07.041
article 2014
Mutations in the GnRH signaling pathway are risk factors for endometriosis
·doi:10.1016/j.fertnstert.2014.07.037
article 2014
Next generation sequencing of families with endometriosis identifies new genomic regions likely to contribute to heritability
·doi:10.1016/j.fertnstert.2014.07.260
article 2014
Rare mutations in WNT signaling pathways are risk factors for endometriosis
·doi:10.1016/j.fertnstert.2014.07.038
article 2013
Genome-Wide Association Study Link Novel Loci to Endometriosis
PloS one ·doi:10.1371/journal.pone.0058257

Endometriosis is a common gynecological condition with complex etiology defined by the presence of endometrial glands and stroma outside the womb. Endometriosis is a common cause of both cyclic and chronic pelvic pain, reduced fertility, an…

article 2012
Comparing apples and oranges: molecular pathogenesis of endometriosis varies by patient ancestry
·doi:10.1016/j.fertnstert.2012.07.488
article 2012
Genetic prediction of endometriosis in women seeking assisted reproductive technologies
·doi:10.1016/j.fertnstert.2012.07.923
article 2012
KRAS and LCS6 show no evidence of association with endometriosis
·doi:10.1016/j.fertnstert.2012.07.785
article 2012
Rare genetic variants useful for non-invasive diagnosis and prediction of endometriosis
·doi:10.1016/j.fertnstert.2012.07.038
article 2012
Replication of endometriosis GWAS signal across multiple studies support involvement of WNT4
·doi:10.1016/j.fertnstert.2012.07.1153
article 2012
Sipping from the firehose: complete genome sequencing of endometriosis patients
·doi:10.1016/j.fertnstert.2012.07.243