Poole EM — Endo Lab

2014

Genome-wide association study of subtype-specific epithelial ovarian cancer risk alleles using pooled DNA.

Human genetics ·doi:10.1007/s00439-013-1383-3

Epithelial ovarian cancer (EOC) is a heterogeneous cancer with both genetic and environmental risk factors. Variants influencing the risk of developing the less-common EOC subtypes have not been fully investigated. We performed a genome-wid…

2013

Epigenetic analysis leads to identification of HNF1B as a subtype-specific susceptibility gene for ovarian cancer.

Nature communications ·doi:10.1038/ncomms2629

HNF1B is overexpressed in clear cell epithelial ovarian cancer, and we observed epigenetic silencing in serous epithelial ovarian cancer, leading us to hypothesize that variation in this gene differentially associates with epithelial ovaria…

2011

Body size in early life and adult levels of insulin-like growth factor 1 and insulin-like growth factor binding protein 3.

American Journal of Epidemiology ·doi:10.1093/aje/kwr123

Body size in early life has been associated with breast cancer risk. This may be partly mediated through the insulin-like growth factor (IGF) pathway. The authors assessed whether birth weight, body fatness at ages 5 and 10 years, and body …