Yu ZC

No ORCID on file · 3 papers in corpus
2023
ARID1A loss activates MAPK signaling via DUSP4 downregulation.
Journal of Biomedical Science ·doi:10.1186/s12929-023-00985-5

BackgroundARID1A, a tumor suppressor gene encoding BAF250, a protein participating in chromatin remodeling, is frequently mutated in endometrium-related malignancies, including ovarian or uterine clear cell carcinoma (CCC) and endometrioid …

2021
A novel human endometrial epithelial cell line for modeling gynecological diseases and for drug screening.
Laboratory investigation; a journal of technical methods and pathology ·doi:10.1038/s41374-021-00624-3

Endometrium-related malignancies including uterine endometrioid carcinoma, ovarian clear cell carcinoma and ovarian endometrioid carcinoma are major types of gynecologic cancer, claiming more than 13,000 women's lives annually in the United…

2020
Inactivation of Arid1a in the endometrium is associated with endometrioid tumorigenesis through transcriptional reprogramming.
Nature communications ·doi:10.1038/s41467-020-16416-0

Somatic inactivating mutations of ARID1A, a SWI/SNF chromatin remodeling gene, are prevalent in human endometrium-related malignancies. To elucidate the mechanisms underlying how ARID1A deleterious mutation contributes to tumorigenesis, we …