Petra Brožič

No ORCID on file · 3 papers in corpus
lab-animal 2012
Expression of human aldo-keto reductase 1C2 in cell lines of peritoneal endometriosis: potential implications in metabolism of progesterone and dydrogesterone and inhibition by progestins
The Journal of steroid biochemistry and molecular biology ·doi:10.1016/j.jsbmb.2011.12.011

The human aldo-keto reductase AKR1C2 converts 5α-dihydrotestosterone to the less active 3α-androstanediol and has a minor 20-ketosteroid reductase activity that metabolises progesterone to 20α-hydroxyprogesterone. AKR1C2 is expressed in dif…

other 2012
Selective inhibitors of aldo-keto reductases AKR1C1 and AKR1C3 discovered by virtual screening of a fragment library
Journal of medicinal chemistry ·doi:10.1021/jm300841n

Human aldo-keto reductases 1C1-1C4 (AKR1C1-AKR1C4) function in vivo as 3-keto-, 17-keto-, and 20-ketosteroid reductases and regulate the activity of androgens, estrogens, and progesterone and the occupancy and transactivation of their corre…

lab-animal 2011
Selectivity and potency of the retroprogesterone dydrogesterone in vitro
Steroids ·doi:10.1016/j.steroids.2011.02.043

Dydrogesterone is widely used for menstrual disorders, endometriosis, threatened and habitual abortion and postmenopausal hormone replacement therapy. Although progestins have a promiscuous nature, dydrogesterone does not have clinically re…