DACK KEVIN NEIL

The present invention relates to a class of EP2 antagonistazetidines of general formula (I), wherein the variables and substituents are as defined herein, and especially to EP2 antagonist compounds, to their use in medicine, particularly in…

This invention relates to a class of pyrrolidine compounds of formula (I), and pharmaceutical ly acceptable derivatives thereof, to their use in med icine, to compositions containing them, and to processes for their preparation. It also rel…

The present invention relates to a class of EP2 antagonistazetidinesof general formula (I), wherein the variables and substituents are as defined herein,and especially to EP2 antagonist compounds, to their use in medicine, particularly in t…

The present invention relates to a class of EP2 antagonistazetidinesof general formula (I), wherein the variables and substituents are as defined herein,and especially to EP2 antagonist compounds, to their use in medicine, particularly in t…

Compounds of formula (I), or pharmaceutically acceptable derivatives thereof, wherein: R1 represents H, C1-6-alkyl, C1-6alkyloxy, C3-8cycloalkyl, or halo; R2 represents H, C1-6alkyl (optionally substituted by R3), phenyl (optionally substit…

Compounds of formula (I), or pharmaceutically acceptable derivatives thereof, wherein: R1 represents H, C1-6alkyl, C1-6alkyloxy, C3-8cycloalkyl, or halo; R2 represents H, C1-6alkyl (optionally substituted by R3), phenyl (optionally substitu…

Compounds of formula (I), or a pharmaceutically acceptable derivative thereof, wherein Rand Rindependently represent H, C1-6alkyl, C3-8cycloalkyl, or halogen; Rrepresents C1-6alkyl, CF3 or aryl; a represents 1 or 2; R, R, Rand Rindependentl…

Compounds of formula (I), or a pharmaceutically acceptable derivative thereof, wherein Rand Rindependently represent H, C1-6alkyl, C3-8cycloalkyl, or halogen; Rrepresents C1-6alkyl, CF3 or aryl; a represents 1 or 2; R, R, Rand Rindependentl…

The present invention relates to a class of EP2 antagonist azetidines of general formula (I) wherein the variables and substituents are as defined herein, and especially to EP2 antagonist compounds, to their use in medicine, particularly in…

The present invention relates to a class of EP2 antagonist azetidines of general formula (I) wherein the variables and substituents are as defined he rein, and especially to EP2 antagonist compounds, to their use in medicine, particularly i…

The invention relates to EP2 antagonist azetidines of formula (I) wherein Ar, R, X, and Z are as defined herein, to their use in medicine, particularly in the treatment of endometriosis and/or uterine fibroids, to intermediates useful in th…

Compounds of Formula (I): and pharmaceutically acceptable salts, solvates (including hydrates) of said compounds and salts, or prodrugs of said compound, or pharmaceutically acceptable salts or solvates of said prodrugs, wherein the substit…

A compound of Formula (IA) or (IB), or a pharmaceutically acceptable salt, solvate (including hydrate) of said compound and salt, or a prodrug of said compound, or a pharmaceutically acceptable salt or solvate of said prodrug, Formula (IA),…

Compounds of formula (1), or a pharmaceutically acceptable derivative thereof, wherein R1 and R3 independently represent H, C1-6alkyl, C3-8cycloalkyl, or halogen R2 represents C1-6alkyl, CF3 or aryl a represents 1 or 2 R4, R5, R7 and R8 ind…

Compounds of Formula (I): and pharmaceutically acceptable salts, solvates (including hydrates) of said compounds and salts, or prodrugs of said compound, or pharmaceutically acceptable salts or solvates of said prodrugs, wherein the substit…

Compounds of formula (I), or a pharmaceutically acceptable derivative thereof, wherein Rand Rindependently represent H, C1-6alkyl, C3-8cycloalkyl, or halogen; Rrepresents C1-6alkyl, CF3 or aryl; a represents 1 or 2; R, R, Rand Rindependentl…

Compounds of formula (I), or a pharmaceutically acceptable derivative thereof, wherein Rand Rindependently represent H, C1-6alkyl, C3-8cycloalkyl, or halogen; Rrepresents C1-6alkyl, CF3 or aryl; a represents 1 or 2; R, R, Rand Rindependentl…

Compounds of formula (1), or a pharmaceutically acceptable derivative thereof,wherein R1 and R3 independently represent H, C1-6alkyl,C3-8cycloalkyl, or halogen; R2 represents C1-6alkyl,CF3 or aryl; a represents 1 or 2; R4, R5, R7and R8 inde…

Compounds of formula (I), or pharmaceutically acceptable derivatives thereof, wherein: Rrepresents H, C1-6-alkyl, C1-6alkyloxy, C3-8cycloalkyl, or halo; Rrepresents H, C1-6alkyl (optionally substituted by R), phenyl (optionally substituted …

Compounds of formula (I), or pharmaceutically acceptable derivatives thereof , wherein: R1 represents H, C1-6alkyl, C1-6alkyloxy, C3-8cycloalkyl, or halo R2 represents H, C1-6alkyl (optionally substituted by R3), phenyl (optionally substitu…

Compounds of formula (I), or pharmaceutically acceptable derivatives thereof, wherein: R represents H, C1-6alkyl, C1-6alkyloxy, C3-8cycloalkyl, or halo; R represents H, C1-6alkyl (optionally substituted by R), phenyl (optionally substituted…