Keira J A Johnston

BACKGROUND: Chronic pain, defined as pain that persists for greater than three months, is a common, understudied condition that affect an estimated 20-30% of the population. Despite a high prevalence and distressing physical and psychologic…

Chronic overlapping pain conditions (COPCs) are a subset of chronic pain conditions commonly comorbid with one another and more prevalent in women and individuals assigned female at birth (AFAB). Pain experience in these conditions may bett…

Here, we present a protocol for finding genetic variation associated with unmeasured traits using common-factor genome-wide association study (GWAS) using genomic structural equation modeling (GenomicSEM), applied here to nociplastic pain. …

BACKGROUND: Chronic pain is a common, poorly understood condition. Genetic studies including genome-wide association studies have identified many relevant variants, which have yet to be translated into full understanding of chronic pain. Tr…

INTRODUCTION: Chronic pain is a common condition with high socioeconomic and public health burden. A wide range of psychiatric conditions are often comorbid with chronic pain and chronic pain conditions, negatively impacting successful trea…