Ali Akoum

No ORCID on file · 88 papers in corpus
observational 2011
Distinct expression of the soluble and the membrane-bound forms of interleukin-1 receptor accessory protein in the endometrium of women with endometriosis
Fertility and sterility ·doi:10.1016/j.fertnstert.2010.12.056

OBJECTIVE: To investigate interleukin (IL) 1 receptor accessory protein (IL1RAcP) expression in the eutopic endometrium of women with endometriosis. DESIGN: Retrospective study. SETTING: Human reproduction research laboratory. PATIENT(S)…

2011
Faculty Opinions recommendation of MicroRNA 135 regulates HOXA10 expression in endometriosis.
·doi:10.3410/f.13357251.14754071
2011
Faculty Opinions recommendation of Research resource: genome-wide profiling of methylated promoters in endometriosis reveals a subtelomeric location of hypermethylation.
·doi:10.3410/f.7507957.7804055
2011
Macrophage migration inhibitory factor stimulates the expression of matrix metalloproteinases 2 and 9 in endometriotic cells and up-regulates their activation level
·doi:10.1016/j.fertnstert.2011.07.521
2010
Faculty Opinions recommendation of Adult physical activity and endometriosis risk.
·doi:10.3410/f.2435956.2071054
2010
Faculty Opinions recommendation of Impaired down-regulation of E-cadherin and beta-catenin protein expression in endometrial epithelial cells in the mid-secretory endometrium of infertile patients with endometriosis.
·doi:10.3410/f.3689960.3413058
lab-animal 2010
Macrophage migration inhibitory factor elicits an angiogenic phenotype in human ectopic endometrial cells and triggers the production of major angiogenic factors via CD44, CD74, and MAPK signaling pathways
The Journal of clinical endocrinology and metabolism ·doi:10.1210/jc.2010-0417

CONTEXT: An active angiogenesis is required for ectopic endometrial tissue growth. Our previous studies led to the identification of macrophage migration inhibitory factor (MIF), which is markedly elevated in active, vascularized, and early…

lab-animal 2010
Macrophage Migration Inhibitory Factor Elicits an Angiogenic Phenotype in Human Ectopic Endometrial Cells and Triggers the Production of Major Angiogenic Factors via CD44, CD74, and MAPK Signaling Pathways
Molecular Endocrinology ·doi:10.1210/mend.24.10.9996

Abstract Context: An active angiogenesis is required for ectopic endometrial tissue growth. Our previous studies led to the identification of macrophage migration inhibitory factor (MIF), which is markedly elevated in active, vascularized, …

2009
Faculty Opinions recommendation of Macrophages and nerve fibres in peritoneal endometriosis.
·doi:10.3410/f.1148197.605334
2009
Faculty Opinions recommendation of MicroRNA expression profiling of eutopic secretory endometrium in women with versus without endometriosis.
·doi:10.3410/f.1166034.626927
2009
Faculty Opinions recommendation of The impact of peritoneal fluid from healthy women and from women with endometriosis on sperm DNA and its relationship to the sperm deformity index.
·doi:10.3410/f.1159671.621070
review 2009
Insights into endometriosis-associated endometrial dysfunctions: a review
Frontiers in bioscience (Elite edition) ·doi:10.2741/E38

Endometriosis is defined as the presence of ectopic endometrial-like tissue outside the uterus cavity. This disease, afflicting women during their reproductive age, is mainly associated with pelvic pain and infertility. Sampson's theory whi…

lab-animal 2009
Up-regulation of cyclooxygenase-2 expression and prostaglandin E2 production in human endometriotic cells by macrophage migration inhibitory factor: involvement of novel kinase signaling pathways
Endocrinology ·doi:10.1210/en.2008-1088

Cyclooxygenase (COX) is the rate-limiting enzyme in the metabolic conversion of arachidonic acid to prostaglandins (PGs), including prostaglandin E(2) (PGE(2)), a major mediator of inflammation and angiogenesis. Herein, we report that macro…

other 2008
Abnormal interleukin 1 receptor types I and II gene expression in eutopic and ectopic endometrial tissues of women with endometriosis
Journal of Reproductive Immunology ·doi:10.1016/j.jri.2007.04.002

Interleukin-1 (IL1) is believed to play a central role in the immuno-inflammatory process associated with endometriosis. IL1 triggers cell activation via its receptor type I (IL1R1), but its receptor type II (IL1R2) is known instead as a sc…

2008
Detection of a positive feedback loop between macrophage migration inhibitory factor (MIF) and estrogen in endometriosis
·doi:10.1016/j.fertnstert.2008.07.945
2008
Faculty Opinions recommendation of Deficiency of immunophilin FKBP52 promotes endometriosis.
·doi:10.3410/f.1132866.589956
2008
Faculty Opinions recommendation of Endometrial-peritoneal interactions during endometriotic lesion establishment.
·doi:10.3410/f.1122790.579875
observational 2008
Faculty Opinions recommendation of Endometriosis is associated with aberrant endometrial expression of telomerase and increased telomere length.
·doi:10.3410/f.1109156.571382

BACKGROUND: In order to test our hypothesis that endometriosis is associated with abnormal expression of telomerase and telomere lengthening in endometrium, we assessed endometrial expression of the human telomerase enzyme and telomere leng…

2008
Faculty Opinions recommendation of Upstream stimulatory factor-2 regulates steroidogenic factor-1 expression in endometriosis.
·doi:10.3410/f.1104931.562037
observational 2008
Imbalance in the peritoneal levels of interleukin 1 and its decoy inhibitory receptor type II in endometriosis women with infertility and pelvic pain
Fertility and sterility ·doi:10.1016/j.fertnstert.2007.06.019

OBJECTIVE: To evaluate the levels of interleukin-1beta (IL1beta) and its inhibitory soluble interleukin-1 receptor type II (IL1R2) in the peritoneal fluid (PF) of normal women and patients with endometriosis suffering from pelvic pain and i…

2008
Induction of cyclooxygenase-2 expression and prostaglandin E2 secretion by macrophage migration inhibitory factor in ectopic endometrial cells: role in the pathophysiology of endometriosis
·doi:10.1016/j.fertnstert.2008.07.943
lab-animal 2008
Involvement of nuclear factor-kappaB in macrophage migration inhibitory factor gene transcription up-regulation induced by interleukin- 1 beta in ectopic endometrial cells
Fertility and sterility ·doi:10.1016/j.fertnstert.2008.05.017

OBJECTIVE: To investigate the involvement of the nuclear factor (NF)-kappaB in the interleukin (IL)-1 beta-mediated macrophage migration inhibitory factor (MIF) gene activation. DESIGN: Prospective study. SETTING: Human reproduction resea…

2008
Macrophage migration inhibitory factor (MIF)-induced signaling pathways in human endometrial stromal cells of women with and without endometriosis
·doi:10.1016/j.fertnstert.2008.07.249
2008
Marked expression of prostaglandin E synthases in endometriosis
·doi:10.1016/j.fertnstert.2008.07.250
other 2007
Direct effect of macrophage migration inhibitory factor on sperm function: possible involvement in endometriosis-associated infertility
Fertility and sterility ·doi:10.1016/j.fertnstert.2007.04.002

OBJECTIVE: To evaluate the effect of macrophage migration inhibitory factor (MIF) on sperm capacitation, a maturational process that occurs in the female reproductive tract and enables spermatozoa to become fully competent at fertilizing th…