Tao Guo

No ORCID on file · 5 papers in corpus
lab-animal 2025
Suppression of METTL3 expression attenuated matrix stiffness-induced vaginal fibroblast-to-myofibroblast differentiation and abnormal modulation of the extracellular matrix in pelvic organ prolapse
Chinese medical journal ·doi:10.1097/cm9.0000000000003409

BACKGROUND: Fibrosis of the connective tissue in the vaginal wall predominates in pelvic organ prolapse (POP), which is characterized by excessive fibroblast-to-myofibroblast differentiation and abnormal deposition of the extracellular matr…

other 2023
An atypical site endometriosis treated by multidisciplinary cooperation
Asian journal of surgery ·doi:10.1016/j.asjsur.2023.07.085
lab-animal 2022
Mechanical stress influences the morphology and function of human uterosacral ligament fibroblasts and activates the p38 MAPK pathway
International urogynecology journal ·doi:10.1007/s00192-021-04850-7

INTRODUCTION AND HYPOTHESIS: Pelvic organ prolapse (POP) is a common condition in older women that affects quality of life. Mechanical injury of the pelvic floor support system contributes to POP development. In our study, we aimed to exami…

lab-animal 2022
The protective effect of 17 β-estradiol on human uterosacral ligament fibroblasts from postmenopausal women with pelvic organ prolapse
Frontiers in physiology ·doi:10.3389/fphys.2022.980843

This study aims to explore the protective effects of 17 β-estradiol on the human uterosacral ligament fibroblasts (hUSLFs) under static or stretched conditions. The experiments were performed on hUSLFs derived from pelvic organ prolapse (PO…

review 2021
Cellular Mechanism of Gene Mutations and Potential Therapeutic Targets in Ovarian Cancer
Cancer management and research ·doi:10.2147/cmar.s292992

Ovarian cancer is a common and complex malignancy with poor prognostic outcome. Most women with ovarian cancer are diagnosed with advanced stage disease due to a lack of effective detection strategies in the early stage. Traditional treatme…