Dissecting Cardiovascular Responses to a Fixed-Interval Volitional Sighing Task Using a Mixed Modeling Approach

Dissecting Cardiovascular Responses to a Fixed-Interval Volitional Sighing Task Using a Mixed Modeling Approach | Authorea try { document.documentElement.classList.add('js'); } catch (e) { } var _gaq = _gaq || []; _gaq.push(['_setAccount', 'G-8VDV14Y67G']); _gaq.push(['_trackPageview']); (function() { var ga = document.createElement('script'); ga.type = 'text/javascript'; ga.async = true; ga.src = ('https:' == document.location.protocol ? 'https://ssl' : 'http://www') + '.google-analytics.com/ga.js'; var s = document.getElementsByTagName('script')[0]; s.parentNode.insertBefore(ga, s); })(); Skip to main content Preprints Collections Wiley Open Research IET Open Research Ecological Society of Japan All Collections About About Authorea FAQs Contact Us Quick Search anywhere Search for preprint articles, keywords, etc. Search Search ADVANCED SEARCH SCROLL Psychophysiology This is a preprint and has not been peer reviewed. Data may be preliminary. 17 April 2025 V1 Latest version Share on Dissecting Cardiovascular Responses to a Fixed-Interval Volitional Sighing Task Using a Mixed Modeling Approach Authors : Neel Muzumdar 0000-0002-0776-4498 [email protected] , Kelly Sun , Samuel Zhang , Kelsey Piersol , Anthony Pawlak 0000-0002-5304-2752 , Marsha E. Bates , and Jennifer Buckman 0000-0002-1898-5499 Authors Info & Affiliations https://doi.org/10.22541/au.174488992.29712553/v1 243 views 137 downloads Contents Abstract Supplementary Material Information & Authors Metrics & Citations View Options References Figures Tables Media Share Abstract Background: Sighing is integral to psychophysiological regulation. Volitional sighing tasks have been developed to overcome methodological issues of studying naturalistic sighing and advance research on sigh physiology. This study uses fixed-interval volitional sighing (FIVS), which rhythmically paces sighs at different frequencies, to dissect cardiovascular and autonomic responses during FIVS and explore potential sex differences in cardiovascular response dynamics. Methods: Healthy college students (n=250, 65% female) completed a baseline task and two FIVS tasks (0.033Hz and 0.066Hz) while continuous HR, BP, and respiration were measured. Using a mixed model and a priori cardiorespiratory assumptions, we isolated HR, low-frequency heart rate variability (LF-HRV), high-frequency HRV (HF-HRV), pulse transit time variability (PTTv), and mean arterial pressure (MAP) responses to sighing. Results: FIVS produced non-habituating cardiovascular responses with spectral peaks corresponding to sighing frequency. HR, LF-HRV, PTTv, and MAP increased significantly from baseline to both FIVS tasks, with greater changes observed during 0.066Hz FIVS. HF-HRV decreased only during the 0.066Hz task. Males exhibited greater increases than females in HR and PTTv, but smaller decreases in HF-HRV, from baseline to the FIVS tasks. Conclusions: Volitional sighing directly elicits graded cardiac, vascular, and autonomic responses in a frequency-dependent manner. These responses support sighing as a sympathetic challenge, which, like strenuous physical activity, may lead to longer-term improvements in autonomic balance. Sex differences in cardiovascular mobilization processes indicate potentially distinct regulatory mechanisms. This research advances our understanding of sigh physiology and suggests FIVS may serve as a valuable tool for assessing subtle variations in cardiovascular function. Supplementary Material File (sigh_cardio_manu.docx) Download 1.24 MB Information & Authors Information Version history V1 Version 1 17 April 2025 Copyright This work is licensed under a Non Exclusive No Reuse License. Collection Psychophysiology Authors Affiliations Neel Muzumdar 0000-0002-0776-4498 [email protected] Rutgers University New Brunswick View all articles by this author Kelly Sun Rutgers University New Brunswick View all articles by this author Samuel Zhang Rutgers University New Brunswick View all articles by this author Kelsey Piersol Rutgers University New Brunswick View all articles by this author Anthony Pawlak 0000-0002-5304-2752 Rutgers University New Brunswick View all articles by this author Marsha E. Bates Rutgers University New Brunswick View all articles by this author Jennifer Buckman 0000-0002-1898-5499 Rutgers University New Brunswick View all articles by this author Metrics & Citations Metrics Article Usage 243 views 137 downloads .FvxKWukQNSOunydq8rnd { width: 100px; } Citations Download citation Neel Muzumdar, Kelly Sun, Samuel Zhang, et al. Dissecting Cardiovascular Responses to a Fixed-Interval Volitional Sighing Task Using a Mixed Modeling Approach. Authorea . 17 April 2025. DOI: https://doi.org/10.22541/au.174488992.29712553/v1 If you have the appropriate software installed, you can download article citation data to the citation manager of your choice. Simply select your manager software from the list below and click Download. For more information or tips please see 'Downloading to a citation manager' in the Help menu . Format Please select one from the list RIS (ProCite, Reference Manager) EndNote BibTex Medlars RefWorks Direct import Tips for downloading citations document.getElementById('citMgrHelpLink').addEventListener('click', function() { popupHelp(this.href); return false; }); $(".js__slcInclude").on("change", function(e){ if ($(this).val() == 'refworks') $('#direct').prop("checked", false); $('#direct').prop("disabled", ($(this).val() == 'refworks')); }); View Options View options PDF View PDF Figures Tables Media Share Share Share article link Copy Link Copied! Copying failed. 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