{"paper_id":"ffa1699d-3358-4541-9823-75e1262f0dec","body_text":"Abstract\nThis study is to identify factors and patient symptomatology affecting ovarian response in women with endometriosis who seek fertility preservation. An observational cross-sectional study was conducted from July 2017 to May 2020 at a tertiary university-affiliated medical center. We included patients who were treated in the endometriosis clinic and underwent fertility preservation. Patients completed an online questionnaire that was cross-referenced with electronic charts. An analysis related to patient data and fertility preservation cycles and a mediation analysis were performed. The mean patient age at time of fertility preservation was 35.2 (± 4.9) years. The mean accumulated number of oocytes vitrified per patient was 16.7 (± 12.1) oocytes. The correlation coefficient assessed between the number of oocytes vitrified per cycle and AMH was significantly positive at +0.472, p = 0.006. The examined reported symptoms were lethargy, chronic pelvic pain, dyschezia, dyspareunia, bowel-associated symptoms, and urinary tract symptoms. The number of oocytes vitrified correlated with the number of reported symptoms and clinical characteristics at − 0.497, p = 0.0001, and − 0.442, p = 0.0001, respectively. In a mediation analysis, the potential causality of surgical intervention in the relationship between the number of symptoms and ovarian response was − 0.300 (95% CI [0.15, 1.905], p = 0.05), and the calculated proportion of mediation was estimated to be 17%. We observed a significant negative association between the number of clinical symptoms and the quantity of vitrified oocytes. This relationship was only partly associated with prior surgical intervention. 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Fertil Steril 2018;109(6):993-9.\nAuthor information\nAuthors and Affiliations\nCorresponding author\nEthics declarations\nEthics Approval\nThis study was performed in line with the principles of the Declaration of Helsinki. Approval was granted by the Ethics Committee of Tel Aviv Medical Center IRB approval number: 0149-20-TLV.\nConsent to Participate\nNot applicable.\nConsent for Publication\nNot applicable.\nConflict of Interest\nThe authors declare no competing interests.\nAdditional information\nPublisher’s Note\nSpringer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.\nRights and permissions\nSpringer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law.\nAbout this article\nCite this article\nFouks, Y., Goaz, S., Ryley, D. et al. Fertility Preservation in Endometriosis: Does Patient Symptomatology Affect the Extent of the Ovarian Response?. Reprod. Sci. 30, 2439–2448 (2023). https://doi.org/10.1007/s43032-023-01180-5\nReceived:\nAccepted:\nPublished:\nVersion of record:\nIssue date:\nDOI: https://doi.org/10.1007/s43032-023-01180-5","source_license":"CC0","license_restricted":false}