{"paper_id":"fe9fff3d-be4a-4e06-809e-653acee752c0","body_text":"Abstract\nAdenomyosis affects about 20% of women of reproductive age and is responsible for menorrhagia, dysmenorrhea, menstrual pelvic pain, dyspareunia, and infertility [1]. The causes of adenomyosis-related pain are unclear. When combined with endometriosis, especially deep infiltrating endometriosis (DIE), dysmenorrhea is more severe in patients with adenomyosis, and the chance of progressive dysmenorrhea will increase. Other pain mechanisms related to adenomyosis include abnormal uterine contractility and abnormal expression of the oxytocin receptor (OTR), abnormal expression of prostaglandin (PG) and cyclooxygenase 2 (COX-2), abnormal growth and distribution of local nerve fibers, neuropeptides, macrophages, abnormal secretion of cells and inflammatory factors, and so on. 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Gynecol Endocrinol. 2017;33(Supp 1):44–6.\nAuthor information\nAuthors and Affiliations\nEditor information\nEditors and Affiliations\nRights and permissions\nCopyright information\n© 2021 The Author(s), under exclusive license to Springer Nature Singapore Pte Ltd.\nAbout this chapter\nCite this chapter\nLi, X., Deng, S., Leng, J. (2021). Adenomyosis and Pain. In: Xue, M., Leng, J., Wong, F. (eds) Adenomyosis. Springer, Singapore. https://doi.org/10.1007/978-981-33-4095-4_5\nDownload citation\nDOI: https://doi.org/10.1007/978-981-33-4095-4_5\nPublished:\nPublisher Name: Springer, Singapore\nPrint ISBN: 978-981-33-4094-7\nOnline ISBN: 978-981-33-4095-4\neBook Packages: MedicineMedicine (R0)","source_license":"CC0","license_restricted":false}