{"paper_id":"fd2425cc-689d-42f1-9a01-406edeab2348","body_text":"The Role of Proinflamatory Cytokines in the Development of Clinical Picture of Myoma and Adenomyosis\nDOI:\nhttps://doi.org/10.37506/ijfmt.v14i4.12787Keywords:\nUterine myoma, adenomyosis, pro-inflammatory cytokines IL-1, IL-6, TNF, anti-inflammatory cytokines IL-10, VEGF.Abstract\nThe goal of research was to study the cytokine status in women with a combination of fibroids and\nadenomyosis to determine their role in the course of the disease. Method 165 women with uterine myoma\nand/or adenomyosis were examined. Patients were divided into 3 groups: 1-group - 75 women with a\ncombined form of myoma and adenomyosis, 2-group - 47 women with diffuse adenomyosis, 3-group - 43\nwomen with uterine myoma. The study was conducted in 2017-2018, on the basis of the Tashkent Medical\nAcademy in the department of gynecology of the obstetric-gynecological complex No. 9 of Tashkent city.\nThe research method were a dynamic study of node blood flow by ultrasound with dopplerometry and an\nimmunological blood test. For myoma 5 mg ulipristal acetate was prescribed for treatment for 3 months for\nat least 2 courses by 3 months with a 2 month break, and for adenomyosis - 2 mg dienogest for 6 months\ncontinuously. For the combined form of myoma and adenomyosis, treatment was started with dienogest for\n6 months continuously, then UPA was prescribed for 3 months.\nResults: The determination of the level of pro-inflammatory cytokines in patients before treatment showed\nthe following results: the level of IL-1, IL-6 and TNF-? was higher in all three groups than in the control\ngroup, and in the group with combined pathology IL-6 was 1,5 times higher than in groups with isolated\npathologies. After therapy, the decrease in the levels of IL-1, IL-6, and TNF-? was observed in all three\ngroups. Also the level of anti-inflammatory cytokines IL-10 and VEGF exceeded significantly the control\ngroup, especially in the group with combined pathology, after the treatment, their level decreased significantly.\nDiscussion: An increase in the level of cytokines in the blood is most pronounced in combined forms of\nmyoma and adenomyosis compared with isolated forms of myoma and adenomyosis.\nDownloads\nPublished\nIssue\nSection\nLicense\nhttps://creativecommons.org/licenses/by-nc/2.0/deed.en","source_license":"CC0","license_restricted":false}