{"paper_id":"fc9e7216-f3a4-4296-9a71-cd5a335afb3e","body_text":"Abstract\nThis study examines the distribution of estrogen receptors (ESR), progesterone receptors (Pgr), and the chaperone immunophilin FKBP52 in the eutopic endometrium in a baboon model of endometriosis during the window of receptivity to determine if their aberrant distribution contributes to reduced fecundity. Endometriosis was induced by inoculation of menstrual endometrium into the peritoneal cavity. Eutopic endometrium was collected at 3, 6, 9, 12, and 15 months postinoculation. Western blot (WB) and immunohistochemical analyses were performed. Isolated endometrial stromal cells were cultured in the presence or absence of steroid hormones. In animals with endometriosis, ESR-1 (ER-α) decreased in endometrial stromal cells, while ESR-2 (ER-β) was reduced in both glandular epithelial (GE) and stromal cells. Immunoreactive total Pgr was markedly diminished in the GE, which was confirmed by WB analysis. Furthermore, treatment of isolated stromal cells from baboons with endometriosis with hormones did not increase levels of PRA or PRB as in control baboons. FKBP52 was also reduced in the eutopic endometrium of baboons with endometriosis. Endometriosis results in an aberrant distribution of ESR-1, ESR-2, Pgr, and FKBP52 in the eutopic endometrium. The authors propose that a dysregulation in the paracrine signaling between the endometrial stromal and GE cells reduces the responsiveness of Pgr, creating an endometrial environment that is unsuitable for implantation.\nSimilar content being viewed by others\nChange history\n30 December 2007\nIn the article “The Altered Distribution of the Steroid Hormone Receptors and the Chaperone Immunophilin FKBP52 in a Baboon Model of Endometriosis Is Associated With Progesterone Resistance During the Window of Uterine Receptivity” by Kevin S. Jackson, PhD, Allison Brudney, BS, Julie M. Hastings, PhD, Patricia A. Mavrogianis, MS, J. 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Fertil Steril. 1997;68:613–625.\nAuthor information\nAuthors and Affiliations\nCorresponding author\nAdditional information\nThis work was supported by the National Institutes of Health National Institute of Child Health and Human Development Specialized Cooperative Centers Program in Reproduction Research (SCCPRR) U54 HD40093 (to ATF.), a minority postdoctoral training supplement (to KSJ), and HD044715 (to JJK.).\nRights and permissions\nAbout this article\nCite this article\nJackson, K.S., Brudney, A., Hastings, J.M. et al. The Altered Distribution of the Steroid Hormone Receptors and the Chaperone Immunophilin FKBP52 in a Baboon Model of Endometriosis Is Associated With Progesterone Resistance During the Window of Uterine Receptivity. Reprod. Sci. 14, 137–150 (2007). https://doi.org/10.1177/1933719106298409\nPublished:\nIssue date:\nDOI: https://doi.org/10.1177/1933719106298409","source_license":"CC0","license_restricted":false}