{"paper_id":"f9cbb197-3099-4aee-9893-8ca821b80f75","body_text":"Abstract\nAim\nSodium-glucose cotransporter 2 inhibitors (SGLT2is) can improve long-term cardio-renal outcomes in patients with diabetes, heart failure (HF), or renal failure. We aimed to investigate the association of SGLT2is with the risks of various cardiovascular and reproductive diseases.\nMethods\nLarge-scale randomized trials enrolling more than 1000 participants and assessing SGLT2is were included. Outcomes of interest were the various serious adverse events related to cardiovascular or reproductive diseases. Meta-analysis was done to generate pooled risk ratio (RR) and 95% confidence interval (CI).\nResults\nWe included 14 large trials and evaluated 169 types of cardiovascular and reproductive diseases. SGLT2is were significantly associated with the lower risks of 13 types of cardiovascular diseases, e.g., cardiac failure chronic (RR 0.70, 95% CI 0.57–0.87), cardiac failure congestive (RR 0.74, 95% CI 0.66–0.83), acute cardiac failure (RR 0.72, 95% CI 0.60–0.86), coronary artery disease (RR 0.75, 95% CI 0.58–0.97), ischemic cardiomyopathy (RR 0.72, 95% CI 0.52–0.99), atrial fibrillation (RR 0.88, 95% CI 0.78–0.99), bradycardia (RR 0.72, 95% CI 0.53–0.99), and hypertension (RR 0.70, 95% CI 0.54–0.91). SGLT2is were not significantly associated with 18 types of reproductive diseases, e.g., adenomyosis, endometrial hyperplasia, and metrorrhagia. Although SGLT2is were observed to have a significant association with a higher risk of uterine prolapse, the 95% CI of RR for this outcome was relatively wide.\nConclusion\nThis meta-analysis confirms the benefits of SGLT2is against chronic congestive HF again; reveals the possible benefits of SGLT2is against acute HF, myocardial infarction, arrhythmias, and hypertension; and identifies that SGLT2is are safe in general for the reproductive system.\nAccess this article\nWe’re sorry, something doesn't seem to be working properly.\nPlease try refreshing the page. If that doesn't work, please contact support so we can address the problem.\nSimilar content being viewed by others\nData availability\nThe data that support the findings of this study are available from the corresponding author on reasonable request.\nReferences\nT.A. Zelniker, S.D. Wiviott, I. Raz, K. Im, E.L. Goodrich, M.P. Bonaca et al. 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Med. 2(11), 1203–1230 (2021). https://doi.org/10.1016/j.medj.2021.10.004\nFunding\nThis work is supported by the following fundings: (1) Yunnan revitalization talent support program (2023-KHRCBZ-B08); (2) Social development projects of Yunnan Province (202302AA310044); (3) Yunnan Province “Thriving Yunnan Talent Support Program” (XDYC-MY-2022-0055); (4) Kunming University of Science and Technology Medical School Research and Development Funding-National Research Project Incubation Plan (SRDP-2023-003); and (5) National Natural Science Foundation of China (No. 82360305).\nAuthor information\nAuthors and Affiliations\nCorresponding authors\nEthics declarations\nConflict of interest\nThe authors declare no competing interests.\nAdditional information\nPublisher’s note Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.\nThese authors contributed equally: Lei Li, Yun-Hua Dong\nRights and permissions\nSpringer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law.\nAbout this article\nCite this article\nLi, L., Dong, YH., Bai, Y. et al. Association of SGLT2is with cardiovascular and reproductive diseases: a meta-analysis based on 14 large-scale randomized trials. Endocrine 84, 836–841 (2024). https://doi.org/10.1007/s12020-023-03618-x\nReceived:\nAccepted:\nPublished:\nVersion of record:\nIssue date:\nDOI: https://doi.org/10.1007/s12020-023-03618-x","source_license":"public-domain-us","license_restricted":false}