{"paper_id":"f5e77eff-4f26-46a1-8e39-8f9a29450325","body_text":"Interesting Image\nTargeting Imaging Modality in the Diagnosis of Endometriosis: 68 Ga-FAPI-04 PET/CT\n- Hatice Uslu\n- Hamza A. Kösem\n- Meryem Hocaoglu\n- Burak Canıtez\n- Dilruba Şahin\nClinical Nuclear Medicine Publish Ahead of Print, August 24, 2026. | DOI: 10.1097/RLU.0000000000006622\nEndometriosis is a chronic condition in reproductive-age women, and diagnosis can be delayed for 4–11 years due to nonspecific symptoms and limited imaging. This underscores the need for new methods to overcome these diagnostic challenges. Fibroblast activation protein, strongly expressed in the perilesional stroma of endometriotic lesions, is a promising PET target. We included 8 women who underwent 68Ga-FAPI-04 PET/CT for cyclic pelvic or extrapelvic pain and solid nodular lesions, later histopathologically confirmed as endometriosis. In these patients, we showed the targeting diagnostic potential of FAPI PET/CT and endometriotic foci with high accuracy compared with other imaging methods.\nEndometriosis is a chronic condition in reproductive-age women, and diagnosis can be delayed for 4–11 years because symptoms are nonspecific and standard imaging is limited. Fibroblast activation protein, which is strongly expressed in the perilesional stroma of endometriotic lesions, is a promising PET target. This study included 8 women who underwent 68Ga-FAPI-04 PET/CT for cyclic pelvic or extrapelvic pain and solid nodular lesions that were later histopathologically confirmed as endometriosis. In these patients, FAPI PET/CT showed high diagnostic accuracy for detecting endometriotic foci compared with other imaging methods, suggesting this technique may help overcome current diagnostic challenges in endometriosis.\nText is machine generated and may contain inaccuracies. FAQ\nCopyright © 2026 Wolters Kluwer Health, LLC. All rights reserved.","source_license":"CC0","license_restricted":false}