{"paper_id":"f083996a-f69d-4d69-8408-55a51a7f87d8","body_text":"A 76-year-old man suffered from recurrent abdominal pain and distention. The contract-enhanced computed tomography (CT) and endoscopic ultrasound (EUS) exams revealed the presence of a stone in common bile duct (CBD) (\n Fig. 1 \n a \n) and concerning evidence of gallbladder wall thickening, suggestive of either gallbladder adenomyosis or gallbladder carcinoma (\n Fig. 1 \n b \n,\n c \n). In order to distinguish benign adenomyosis from malignant carcinoma, together with treatment of the CBD stone, we sequentially performed endoscopic basket retrieval and target biopsies of the gallbladder.\na \nEndoscopic ultrasound showed the stone in the common bile duct (CBD) (red circle).\n b \nContrast-enhanced abdominal computed tomography revealed the contrast-enhanced localized thickening of the gallbladder wall (red arrows).\n c \nThe localized contrast-enhanced gallbladder wall thickness as shown in the endoscopic ultrasound image (red circle).\nIn the first procedure, contrast imaging revealed CBD dilation (\n Fig. 2 \n a \n). Under the navigation of the guidewire, the cholangioscope was introduced into the CBD and the stone was then successfully extracted (\n Fig. 2 \n b \n). Subsequently, another guidewire was advanced into the gallbladder lumen under the guidance of the cholangioscope (\n Fig. 2 \n c \n), facilitating the subsequent placement of the stent along the segment extending from the gallbladder to Vater’s ampulla, creating an approach for subsequent cholangioscopy during the second procedure (\n Fig. 2 \n d \n). Meanwhile, a double-pigtail stent was deployed within the CBD to ensure fluent bile drainage.\na \nCholangiography showed the dilation of CBD.\n b \nThe stone was extracted by the retrieval basket.\n c \nThe guidewire was advanced into the gallbladder lumen under direct vision of the cholangioscope.\n d \nCholangiography showed the placement of the metal stent and double-pigtail stent.\nThree days later, we performed the second endoscopic retrograde cholangiopancreatography (ERCP). The cholangioscope entered the gallbladder along the formally established pathway under the guidance of the guidewire. Owing to the excellent dexterity of the cholangioscope, retroflexion can be achieved in the constricted gallbladder lumen, so that we could directly observe the multifocal papillary neoplasm at the gallbladder neck (\n Fig. 3 \n a \n,\n b \n). Subsequently, target biopsies were taken and then pathology confirmed high-grade intraepithelial neoplasia. Stents were removed during duodenoscope withdrawal (\n Fig. 3 \n c \n,\n d \n;\n Video 1 \n).\na \nMultifocal irregular papillary proliferations were observed at the gallbladder neck in retroflexion.\n b \nContrast imaging presented the cholangioscope in the retroflex position.\n c \nTarget biopsies were taken by forceps.\n d \nContrast imaging presented the process of the biopsy.\nCholangioscopy-guided stone extraction and biopsy.\nVideo 1\nThe patient then underwent laparoscopic cholecystectomy. Postoperative histopathology confirmed the presence of highly differentiated gallbladder adenocarcinoma.\nAs this case shows, while gallbladder neoplasms can be easily detected by US or CT, making a pathological diagnosis in the early stage remains challenging, often necessitating endoscopic ultrasound-guided fine needle aspiration (EUS-FNA)\n 1 \n. This case suggests a potential option for early precise diagnosis of a gallbladder neoplasm.\nEndoscopy_UCTN_Code_TTT_1AR_2AD","source_license":"CC-BY-4.0","license_restricted":false}