{"paper_id":"f00803e9-3586-45b7-810d-25d827f5df1d","body_text":"Abstract\nIntroduction\nThe pathogen-associated molecular patterns and the danger-associated molecular patterns are possibly responsible for the activation of the inflammatory process in endometriosis through the activation of toll-like receptors (TLRs).\nObjective\nThe aim of this systematic review was to critically analyze the findings of published articles on TLRs in endometriosis.\nMethods\nThe keywords used were “endometriosis” and “toll-like” and the search was performed in Pubmed, Scielo and Lilacs databases. This study followed the PRISMA guidelines and the risk of bias of articles was conducted by Newcastle–Ottawa scale (NOS).\nResults\nOverall, the studies analyzed in this review point toward an increased expression of TLRs two, four and nine in women with endometriosis. 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J Reprod Immunol. https://doi.org/10.1016/j.jri.2018.02.003\nFunding\nThis research did not receive any specific grant from any funding agency in the public, commercial, or not-for-profit sector.\nAuthor information\nAuthors and Affiliations\nContributions\nBCA and SP contributed to conception and design of the systematic review. BCA conducted the literature search, title/abstract review, abstracted. BCA and SP conducted the quality-assessed the included studies. FM prepared the Fig. 3, reviewed, and edited the manuscript. BCA and SP contributed to writing and revising the final manuscript. All authors read and approved the final manuscript.\nCorresponding author\nEthics declarations\nConflict of interest\nThe authors declare that they have no conflict of interest.\nEthical approval\nThis is an observational study. The Research Ethics Committee at Hospital Israelita Albert Einstein–CEP/Einstein, has confirmed that no ethical approval is required.\nAdditional information\nPublisher's Note\nSpringer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.\nSupplementary Information\nBelow is the link to the electronic supplementary material.\nRights and permissions\nAbout this article\nCite this article\nde Azevedo, B.C., Mansur, F. & Podgaec, S. A systematic review of toll-like receptors in endometriosis. Arch Gynecol Obstet 304, 309–316 (2021). https://doi.org/10.1007/s00404-021-06075-x\nReceived:\nAccepted:\nPublished:\nVersion of record:\nIssue date:\nDOI: https://doi.org/10.1007/s00404-021-06075-x","source_license":"CC0","license_restricted":false}