{"paper_id":"f006ad16-6c40-4609-8927-9156e561df82","body_text":"Abstract\nDuring the last years, sophisticated imaging technologies have been introduced in gynecology research, which allow for the repetitive and non-invasive in vivo analysis of dynamic processes within female reproductive tissues of small animals. These include intravital fluorescence microscopy, bioluminescence, ultrasound biomicroscopy, computed tomography (CT) and magnetic resonance imaging (MRI). Due to their individual advantages and disadvantages, each of these technologies has specific indications in different fields of gynecology research. Intravital fluorescence microscopy of transplanted ovarian tissue offers the possibility to gain new insights into the regulatory mechanisms of physiological angiogenesis during folliculogenesis and corpus luteum formation. Dynamic contrast-enhanced MRI enables for the non-invasive determination of placental perfusion and permeability in mouse models of severe pregnancy disorders. In addition, bioluminescence, ultrasound biomicroscopy and CT are useful tools to test the efficacy of novel therapeutic strategies for the treatment of gynecologic tumors or endometriotic lesions. Accordingly, small animal imaging represents an essential part of preclinical gynecology research, which does not only improve our knowledge about physiological and pathological processes within the female reproductive organs, but also critically contributes to the establishment of future therapies for severe gynecological disorders.\nAccess this chapter\nTax calculation will be finalised at checkout\nPurchases are for personal use only\nSimilar content being viewed by others\nReferences\nAkirav C, Lu Y, Mu J, Qu DW, Zhou YQ, Stevin J, Holmyard D, Foster FS, Adamson SL (2005) ultrasonic detection and developmental changes in calcification of the placenta during normal pregnancy in mice. Placenta 26(2–3):129–137\nBecker CM, Wright RD, Satchi-Fainaro R, Funakoshi T, Folkman J, Kung AL, D’Amato RJ (2006) A novel noninvasive model of endometriosis for monitoring the efficacy of antiangiogenic therapy. 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Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-12945-2_30\nDownload citation\nDOI: https://doi.org/10.1007/978-3-642-12945-2_30\nPublisher Name: Springer, Berlin, Heidelberg\nPrint ISBN: 978-3-642-12944-5\nOnline ISBN: 978-3-642-12945-2\neBook Packages: MedicineMedicine (R0)\nKeywords\n- Ovarian Tissue\n- Endometriotic Lesion\n- Syrian Golden Hamster\n- Functional Capillary Density\n- Female Reproductive Organ\nThese keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.","source_license":"CC0","license_restricted":false}