{"paper_id":"ef16a400-e73b-41dd-95b5-7322d21b48ab","body_text":"Abstract\nEndometriosis is a complex disorder with a high socio-economic impact. Development of effective novel drug therapies which can be given to women to relieve chronic pain symptoms without side effects such as hormone suppression is urgently required, but progress has been slow. Several different rodent models of ‘endometriosis’ have been developed, the majority of which mimic aspects of peritoneal disease (e.g. ‘lesions’ in peritoneal cavity either surgically or spontaneously attached to wall, mesentery, fat). Results obtained using these models have informed our understanding of aetiology including evidence for differential expression of regulatory factors in lesions and impacts on pain perception and fertility. Refinement of these models to ensure reproducibility, extension of models to replicate ovarian and deep disease, complementary in vitro approaches and robust experimental design are all needed to ensure preclinical drug testing results in positive findings in clinical trials and translation for patient benefit.\nAccess this chapter\nTax calculation will be finalised at checkout\nPurchases are for personal use only\nSimilar content being viewed by others\nReferences\nAdewuyi EO et al (2020) Shared molecular genetic mechanisms underlie endometriosis and migraine comorbidity. Genes (Basel) 11(3):268\nAfshar Y et al (2013) Changes in eutopic endometrial gene expression during the progression of experimental endometriosis in the baboon, Papio anubis. Biol Reprod 88(2):44\nAgarwal SK et al (2019) Clinical diagnosis of endometriosis: a call to action. 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(eds) Animal Models for Endometriosis. Advances in Anatomy, Embryology and Cell Biology, vol 232. Springer, Cham. https://doi.org/10.1007/978-3-030-51856-1_6\nDownload citation\nDOI: https://doi.org/10.1007/978-3-030-51856-1_6\nPublished:\nPublisher Name: Springer, Cham\nPrint ISBN: 978-3-030-51855-4\nOnline ISBN: 978-3-030-51856-1\neBook Packages: Biomedical and Life SciencesBiomedical and Life Sciences (R0)","source_license":"CC0","license_restricted":false}