{"paper_id":"ed76aa2e-55e0-4c71-8dc8-c3f40d8d2e56","body_text":"Abstract\nIn this commentary, we discuss the associations between adenomyosis, fertility, and obstetric outcomes. A recent meta-analysis on the impact of adenomyosis on reproductive outcomes found a 43% reduction in the odds ratio (OR) for clinical pregnancy and a threefold increase in the risk of miscarriage in women with adenomyosis compared with controls. Moreover, adenomyosis seems to be strongly associated with pre-eclampsia with an OR of almost 8. Also, the risk for small for gestational age was almost fourfold increased, whereas for preterm deliveries was threefold increased. The presence of deep infiltrating endometriosis and adenomyosis seems associated with particularly adverse obstetric outcomes, especially concerning natural conception. Some observations suggest that the probability of clinical pregnancy is considerably low in these cases, around 11.8%. 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All authors read and approved the final manuscript.\nCorresponding author\nEthics declarations\nConflict of Interest\nThe authors declare no competing interests.\nAdditional information\nPublisher’s Note\nSpringer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.\nRights and permissions\nAbout this article\nCite this article\nBuggio, L., Dridi, D. & Barbara, G. Adenomyosis: Impact on Fertility and Obstetric Outcomes. Reprod. Sci. 28, 3081–3084 (2021). https://doi.org/10.1007/s43032-021-00679-z\nReceived:\nAccepted:\nPublished:\nVersion of record:\nIssue date:\nDOI: https://doi.org/10.1007/s43032-021-00679-z","source_license":"CC0","license_restricted":false}