{"paper_id":"ed6f2a54-cf6f-4541-a935-b77829e10bb8","body_text":"Summary\nPre-menopausal (14) and post-menopausal (55) patients with advanced breast cancer were treated with danazol (Danol) for periods ranging between 3 days and 30 months. Of these, 10 patients (14.9%) responded to treatment for 3–19 months (mean 10 months); a further six patients (9%) showed stabilisation of disease; 45 patients showed clear progression of disease following treatment; and eight patients were unassessable. Side-effects occurred in 17 of 69 patients (25%) and necessitated a reduction in therapy in eight cases.\nIt is concluded that danazol is moderately well tolerated and is an effective agent in patients with advanced breast cancer, but the response rate is inferior to that of other agents in current use, such as tamoxifen or aminoglutethimide.\nSimilar content being viewed by others\nReferences\nCoombes RC, Dearnaley D, Humphreys J, Gazet J-C, Ford HT, Nash AG, Mashiter K, Powles TJ (1980a) Danazol treatment of advanced breast cancer. Cancer Treat Rep 64:1073\nCoombes RC, Powles TJ, Gazet J-C, Nash AG Ford HT, McKinna A, Neville AM (1980b) Assessment of biochemical tests to screen for metastases in patients with breast cancer. Lancet I:196\nCoombes RC, Powles TJ, Rees LH Ratcliffe WA, Nash AG, Henk M Ford HT, Gazet J-C, Neville AM (1982) Tamoxifen, aminoglutethimide and danazol: effect of therapy on hormones in post-menopausal patients with breast cancer. Br J Cancer 46:30\nGreeblatt RB, Dmowski WP, Makesh VB (1971) Clinical studies with an antigonadotropin—danazol. Fertil Steril 22:9\nHayward JL, Carbone PP, Heuson J-C, Kumaoka S, Segaloff A, Rubens RD (1977) Assessment of response to therapy in advanced breast cancer. Cancer 39:1289\nMcGuire WL, Carbone PP, Sears ME (1975) Estrogen receptors in human breast cancer. Raven Press, New York pp 1–7\nPotts GO (1977) Pharmacology of danazol. J Int Med Res [Suppl 3] 5:1\nPowles TJ, Gordon C, Coombes RC (1982) Clinical trial of multiple endocrine therapy for metastatic and locally advanced breast cancer with tamoxifen-aminoglutethimide-danazol compared to tamoxifen used alone. Cancer Res 42: 3458S\nAuthor information\nAuthors and Affiliations\nRights and permissions\nAbout this article\nCite this article\nCharles Coombes, R., Perez, D., Gazet, JC. et al. Danazol treatment for advanced breast cancer. Cancer Chemother. Pharmacol. 10, 194–195 (1983). https://doi.org/10.1007/BF00255761\nReceived:\nAccepted:\nIssue date:\nDOI: https://doi.org/10.1007/BF00255761","source_license":"CC0","license_restricted":false}